Netilmicin (1-N-ethylsisomicin) is a semisynthetic aminoglycoside antibiotic, and a derivative of sisomicin, produced by Micromonospora inyoensis. Aminoglycoside antibiotics have the ability to kill a wide variety of bacteria. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.
It was patented in 1973 and approved for medical use in 1981.[2] It was approved for medical use in the UK in December 2019, for the treatment of external infections of the eye.[3] It is on the World Health Organization's List of Essential Medicines.[4]
^"Drug and medical device highlights 2019: Helping you maintain and improve your health". Health Canada. 18 November 2020. Retrieved 28 March 2024.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 508. ISBN 9783527607495.
^"Netilmicin". SPS - Specialist Pharmacy Service. 2 June 2020. Retrieved 21 August 2020.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
Netilmicin (1-N-ethylsisomicin) is a semisynthetic aminoglycoside antibiotic, and a derivative of sisomicin, produced by Micromonospora inyoensis. Aminoglycoside...
different mechanisms of action.) In the following gallery, kanamycin A to netilmicin are examples of the 4,6-disubstituted deoxystreptamine sub-class of aminoglycosides...
which P. vulgaris is known to be sensitive: Ciprofloxacin Ceftazidime Netilmicin Sulbactam or cefoperazone Meropenem Piperacillin/tazobactam Ampicillin/sulbactam...
antibiotics produced by this genus (verdamicin, mutamicin, sisomicin, netilmicin, and retymicin) have their spellings ending in ~micin and not in ~mycin...
Chlamydia trachomatis or Neisseria gonorrhoeae. Amikacin, kanamycin, netilmicin, and tobramycin are alternatives Alternatives are 4th level ATC chemical...
is resistant to vancomycin, chloramphenicol, daptomycin, gentamicin, netilmicin, polymyxin B, streptomycin, teicoplanin, tetracycline, and trimethoprim/sulfamethoxazole...
antibiotics with spellings that end with -micin, such as gentamicin, mutamicin, netilmicin, retymicin, sisomicin, verdamicin, calicheamicin, and the recently found...
or Neisseria gonorrhoeae. Alternatives limited to amikacin, kanamycin, netilmicin, and tobramycin Alternatives limited to 4th level ATC chemical subgroup...
to: ceftizoxime ceftazidime moxalactam cefoxitin gentamicin tobramycin netilmicin Most strains with a few exceptions are also susceptible to: amikacin piperacillin...
the aminoglycoside antibiotics arbekacin, astromicin, isepamicin and netilmicin on the diaphragm and limb muscles in the rabbit". Pharmacology. 63 (3):...
McIntyre N (1997). "A prospective randomized trial of ceftazidime versus netilmicin plus mezlocillin in the empirical therapy of presumed sepsis in cirrhotic...