Neomycin C transaminase (EC 2.6.1.95, neoN (gene)) is an enzyme with systematic name 2-oxoglutarate:neomycin C aminotransferase.[1][2] This enzyme catalyses the following chemical reaction
neomycin C + 2-oxoglutarate 6'''-deamino-6'''-oxoneomycin C + L-glutamate
The reaction occurs in vivo in the opposite direction.
^Huang F, Spiteller D, Koorbanally NA, Li Y, Llewellyn NM, Spencer JB (February 2007). "Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin". ChemBioChem. 8 (3): 283–8. doi:10.1002/cbic.200600371. PMID 17206729.
^Clausnitzer D, Piepersberg W, Wehmeier UF (September 2011). "The oxidoreductases LivQ and NeoQ are responsible for the different 6'-modifications in the aminoglycosides lividomycin and neomycin". Journal of Applied Microbiology. 111 (3): 642–51. doi:10.1111/j.1365-2672.2011.05082.x. PMID 21689223.
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