negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of immune response
regulation of autophagy
negative regulation of toll-like receptor signaling pathway
negative regulation of inflammatory response to antigenic stimulus
regulation of inflammatory response
negative regulation of MAPK cascade
negative regulation of ERK1 and ERK2 cascade
innate immune response
inflammatory response
G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
171389
101613
Ensembl
ENSG00000174885
ENSMUSG00000038745
UniProt
P59044
Q91WS2
RefSeq (mRNA)
NM_001276700 NM_138329
NM_001081389 NM_133946
RefSeq (protein)
NP_001263629 NP_612202
NP_598707
Location (UCSC)
Chr 11: 0.28 – 0.29 Mb
Chr 7: 140.5 – 140.51 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
NLRP6, short for NOD-like receptor family pyrin domain containing 6, is an intracellular protein that plays a role in the immune system. It is also known as NALP6, PYPAF5, PAN3, and CLR11.4, and is one of 14 pyrin domain containing members of the NOD-like receptor family of pattern recognition receptors. As with several other NOD-like receptors, NLRP6's role in immunity is related to its ability to regulate caspase-1 and NF-κB activity.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000174885 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000038745 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Grenier JM, Wang L, Manji GA, et al. (October 2002). "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1". FEBS Lett. 530 (1–3): 73–8. doi:10.1016/S0014-5793(02)03416-6. PMID 12387869. S2CID 25023390.
NLRP6, short for NOD-like receptor family pyrin domain containing 6, is an intracellular protein that plays a role in the immune system. It is also known...
oligomerization domain–like receptor (NLR) family members NOD-2, NLRP3, NLRP6 and NLRP12, may play a role in mediating colorectal cancer. Likewise Helicobacter...
NLRC4, AIM2, and pyrin are the most well-characterized sensors, IFI16, NLRP6, NLRP7, NLRP9b, NLRP10, NLRP12, and CARD8 also play important roles in inflammasome...
many alleles across the population, making it a very polymorphic gene. NLRP6 is highly expressed in the intestine and is involved in fighting viral intestinal...
the species, Nlrp6High PINT, was isolated from colon fecal contents from Nlrp6-/- mice. Hitch; et al. (2022). "A taxonomic note on the genus Prevotella:...
development and is more prevalent in individuals lacking NOD-like receptor 6 (NLRP6). Both R. gnavus and A. muciniphila are bacterial species that are more...
University, advised by Richard Anthony Flavell, in which he discovered the NLRP6 inflammasome. In 2012 Elinav moved to the Weizmann Institute of Science...
I IFN signaling (5) Enterocolitis, macrophage activation syndrome (MAS) NLRP6 Inflammation inducing and imbalanced gut microflora Maintenance of intestinal...