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NACHT, LRR and PYD domains-containing protein 2 is a protein that in humans is encoded by the NLRP2 gene.[5][6][7]
NALP proteins, such as NALP2, are characterized by an N-terminal pyrin domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors(see TLR4). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003).[supplied by OMIM][7][8]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000035177 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nature Reviews. Molecular Cell Biology. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.
^Bertin J, DiStefano PS (December 2000). "The PYRIN domain: a novel motif found in apoptosis and inflammation proteins". Cell Death and Differentiation. 7 (12): 1273–4. doi:10.1038/sj.cdd.4400774. PMID 11270363.
domains-containing protein 2 is a protein that in humans is encoded by the NLRP2 gene. NALP proteins, such as NALP2, are characterized by an N-terminal pyrin...
conformational change is induced by their ligand. Some NLRs such as NLRP1 and NLRP2 have a straightforward mechanism by which the receptor binds to a PAMP triggering...
pro-inflammatory cytokines, such as IL-1 and TNF-α. For example, NLRP11, NLRP5, NLRP2, and NLRP12 have been shown to inhibit different steps in the NF-κB pathway...
stimuli have been linked to the activation of NLRP1. NLRP1B in mice and NLRP2 in rats were found to be responsive to Bacillus anthracis lethal toxin....
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