NLGN4X information

NLGN4X
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2WQZ, 2XB6, 3BE8
Identifiers
Aliases	NLGN4X, ASPGX2, AUTSX2, HLNX, HNL4X, NLGN4, neuroligin 4, X-linked, neuroligin 4 X-linked
External IDs	OMIM: 300427; HomoloGene: 136297; GeneCards: NLGN4X; OMA:NLGN4X - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	6,228,867 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; spinal ganglia; ; cerebellar vermis; ; entorhinal cortex; ; ventricular zone; ; secondary oocyte; ; decidua; ; Brodmann area 46; ; buccal mucosa cell;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; scaffold protein binding; carboxylic ester hydrolase activity; neurexin family protein binding; protein binding; chloride ion binding; cell adhesion molecule binding; signaling receptor activity;
Cellular component	integral component of membrane; postsynaptic membrane; membrane; postsynaptic density; synapse; integral component of plasma membrane; excitatory synapse; cell surface; cell junction; dendrite; plasma membrane; intracellular anatomical structure; spanning component of membrane; presynapse; symmetric, GABA-ergic, inhibitory synapse; asymmetric, glutamatergic, excitatory synapse;
Biological process	cell-cell junction organization; organ growth; neuron cell-cell adhesion; brainstem development; synapse organization; learning; cerebellum development; negative regulation of excitatory postsynaptic potential; presynaptic membrane assembly; vocalization behavior; adult behavior; cell adhesion; neuron differentiation; social behavior; synaptic vesicle endocytosis; postsynaptic membrane assembly; modulation of chemical synaptic transmission; presynapse assembly;
	Sources:Amigo / QuickGO
Orthologs
	57502
	n/a
	ENSG00000146938
	n/a
	Q8N0W4
	n/a
	NM_001282145; NM_001282146; NM_020742; NM_181332
	n/a
	NP_001269074; NP_001269075; NP_065793; NP_851849
	n/a
	Wikidata
View/Edit Human

Neuroligin-4, X-linked is a protein that in humans is encoded by the NLGN4X gene.^[3]^[4]

In the human brain, the synaptic protein NLGN4 is primarily expressed in the cerebral cortex.^[5]

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligins may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs, large (Drosophila) homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Two transcript variants encoding the same protein have been identified for this gene.^[4]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000146938 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (October 1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
^ ^a ^b "Entrez Gene: NLGN4X neuroligin 4, X-linked".
^ Marro SG, Chanda S, Yang N, Janas JA, Valperga G, Trotter J, et al. (June 2019). "Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons". Neuron. 103 (4): 617–626.e6. doi:10.1016/j.neuron.2019.05.043. PMC 6706319. PMID 31257103.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000146938 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10574462-3] Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (October 1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.

[entrez-4] "Entrez Gene: NLGN4X neuroligin 4, X-linked".

[5] Marro SG, Chanda S, Yang N, Janas JA, Valperga G, Trotter J, et al. (June 2019). "Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons". Neuron. 103 (4): 617–626.e6. doi:10.1016/j.neuron.2019.05.043. PMC 6706319. PMID 31257103.

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