NLGN1 information

NLGN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3B3Q
Identifiers
Aliases	NLGN1, NL1, neuroligin 1
External IDs	OMIM: 600568; MGI: 2179435; HomoloGene: 56690; GeneCards: NLGN1; OMA:NLGN1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	174,294,372 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	26,386,609 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; endothelial cell; ; sural nerve; ; Achilles tendon; ; ganglionic eminence; ; stromal cell of endometrium; ; testicle; ; buccal mucosa cell; ; entorhinal cortex; ; corpus callosum;
	Top expressed in
	olfactory tubercle; ; lumbar subsegment of spinal cord; ; piriform cortex; ; substantia nigra; ; dentate gyrus; ; anterior amygdaloid area; ; ventromedial nucleus; ; dentate gyrus of hippocampal formation granule cell; ; lateral septal nucleus; ; globus pallidus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	PDZ domain binding; protein dimerization activity; cell adhesion molecule binding; scaffold protein binding; carboxylic ester hydrolase activity; neurexin family protein binding; amyloid-beta binding; signaling receptor activity;
Cellular component	synapse; integral component of membrane; NMDA selective glutamate receptor complex; Golgi apparatus; cell junction; dendritic shaft; filopodium tip; dendritic spine; postsynaptic membrane; membrane; dendrite; excitatory synapse; external side of plasma membrane; cell surface; presynapse; postsynaptic density; plasma membrane; integral component of postsynaptic membrane; integral component of plasma membrane; spanning component of membrane; postsynapse; glutamatergic synapse; asymmetric, glutamatergic, excitatory synapse; integral component of postsynaptic specialization membrane;
Biological process	NMDA glutamate receptor clustering; positive regulation of ruffle assembly; positive regulation of synaptic vesicle exocytosis; regulation of AMPA receptor activity; rhythmic process; positive regulation of synaptic transmission, glutamatergic; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; positive regulation of circadian sleep/wake cycle, wakefulness; regulation of respiratory gaseous exchange by nervous system process; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; protein heterotetramerization; synaptic vesicle transport; terminal button organization; synapse organization; positive regulation of synaptic transmission, GABAergic; postsynaptic density protein 95 clustering; receptor localization to synapse; protein localization to synapse; neurexin clustering involved in presynaptic membrane assembly; positive regulation of synaptic vesicle endocytosis; synaptic vesicle targeting; protein homooligomerization; positive regulation of protein localization to synapse; neuron projection development; protein targeting; positive regulation of intracellular signal transduction; long-term potentiation; nervous system development; AMPA glutamate receptor clustering; neuronal signal transduction; synaptic vesicle clustering; positive regulation of synaptic vesicle clustering; cytoskeletal matrix organization at active zone; synapse assembly; establishment of protein localization; modulation of chemical synaptic transmission; positive regulation of filopodium assembly; cell adhesion; regulation of neuron differentiation; neuron cell-cell adhesion; positive regulation of dendritic spine development; regulation of NMDA receptor activity; positive regulation of excitatory postsynaptic potential; negative regulation of dendritic spine morphogenesis; positive regulation of synapse assembly; excitatory synapse assembly; positive regulation of presynaptic active zone assembly; retrograde trans-synaptic signaling by trans-synaptic protein complex; synaptic vesicle endocytosis; postsynaptic membrane assembly; presynaptic membrane assembly; cellular response to calcium ion; postsynaptic specialization assembly; presynapse assembly; regulation of presynapse organization; synaptic membrane adhesion; neuron projection arborization;
	Sources:Amigo / QuickGO
Orthologs
	22871
	192167
	ENSG00000169760
	ENSMUSG00000063887
	Q8N2Q7
	Q99K10
NM_014932; NM_001365923; NM_001365924; NM_001365925; NM_001365926;
	NM_001365927; NM_001365928; NM_001365929; NM_001365930; NM_001365931; NM_001365932; NM_001365933; NM_001365934; NM_001365935; NM_001365936
	NM_001163387; NM_138666; NM_001357095; NM_001357096; NM_001357097
NP_055747; NP_001352852; NP_001352853; NP_001352854; NP_001352855;
	NP_001352856; NP_001352857; NP_001352858; NP_001352859; NP_001352860; NP_001352861; NP_001352862; NP_001352863; NP_001352864; NP_001352865
	NP_001156859; NP_619607; NP_001344024; NP_001344025; NP_001344026
	Wikidata
View/Edit Human	View/Edit Mouse

Neuroligin-1 is a protein that in humans is encoded by the NLGN1 gene.^[5]^[6]^[7]

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligin-1 acts as splice site-specific ligand for β-neurexins and has been shown to localize to the postsynaptic compartment at excitatory synapses and is involved in the formation and remodeling of central nervous system synapses.^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169760 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063887 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI (April 2000). "The structure and expression of the human neuroligin-3 gene". Gene. 246 (1–2): 303–10. doi:10.1016/S0378-1119(00)00049-4. PMID 10767552.
^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
^ ^a ^b "Entrez Gene: NLGN1 neuroligin 1".
^ Scheiffele P, Fan J, Choih J, Fetter R, Serafini T (June 2000). "Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons". Cell. 101 (6): 657–69. doi:10.1016/S0092-8674(00)80877-6. PMID 10892652. S2CID 16095623.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169760 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000063887 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10767552-5] Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI (April 2000). "The structure and expression of the human neuroligin-3 gene". Gene. 246 (1–2): 303–10. doi:10.1016/S0378-1119(00)00049-4. PMID 10767552.

[pmid10819331-6] Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.

[entrez-7] "Entrez Gene: NLGN1 neuroligin 1".

[8] Scheiffele P, Fan J, Choih J, Fetter R, Serafini T (June 2000). "Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons". Cell. 101 (6): 657–69. doi:10.1016/S0092-8674(00)80877-6. PMID 10892652. S2CID 16095623.

NLGN1 information

and 9 Related for: NLGN1 information

NLGN1

Neuroligin

Gene nomenclature

DLG4

NRXN1

Carboxylesterase type B

Synaptic stabilization

Epigenetics of autism

Epigenetics of human development