NFATC3 information

NFATC3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XRW, 2XS0
Identifiers
Aliases	NFATC3, NFAT4, NFATX, nuclear factor of activated T-cells 3, nuclear factor of activated T cells 3, NF-AT4c
External IDs	OMIM: 602698 MGI: 103296 HomoloGene: 27827 GeneCards: NFATC3
Gene location (Human)
Chr.	Chromosome 16 (human)
End	68,229,259 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	106,857,169 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; bone marrow cells; ; sperm; ; thymus; ; gastrocnemius muscle; ; lymph node; ; blood; ; deltoid muscle; ; trabecular bone;
	Top expressed in
	thymus; ; blood; ; fossa; ; condyle; ; spleen; ; dermis; ; renal corpuscle; ; abdominal wall; ; cumulus cell; ; conjunctival fornix;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; chromatin binding; transcription factor binding;
Cellular component	cytoplasm; nucleoplasm; nucleus; cytosol; transcription regulator complex;
Biological process	regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription, DNA-templated; Fc-epsilon receptor signaling pathway; inflammatory response; positive regulation of transcription by RNA polymerase II; negative regulation of pri-miRNA transcription by RNA polymerase II; negative regulation of vascular associated smooth muscle cell differentiation; cytokine production; calcineurin-NFAT signaling cascade; multicellular organism development;
	Sources:Amigo / QuickGO
Orthologs
	4775
	18021
	ENSG00000072736
	ENSMUSG00000031902
	Q12968
	P97305
	NM_173165; NM_004555; NM_173163; NM_173164
	NM_010901; NM_001368796; NM_001368797
	NP_004546; NP_775186; NP_775188; NP_004546.1; NP_775188.1
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear factor of activated T-cells, cytoplasmic 3 is a protein that in humans is encoded by the NFATC3 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000072736 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031902 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hoey T, Sun YL, Williamson K, Xu X (May 1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity. 2 (5): 461–72. doi:10.1016/1074-7613(95)90027-6. PMID 7749981.
^ "Entrez Gene: NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000072736 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031902 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7749981-5] Hoey T, Sun YL, Williamson K, Xu X (May 1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity. 2 (5): 461–72. doi:10.1016/1074-7613(95)90027-6. PMID 7749981.

[entrez-6] "Entrez Gene: NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3".

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