Protein-coding gene in the species Homo sapiens
NFATC4 Available structures PDB Ortholog search: PDBe RCSB
Identifiers Aliases NFATC4 , NF-AT3, NF-ATC4, NFAT3, nuclear factor of activated T-cells 4, nuclear factor of activated T cells 4External IDs OMIM: 602699; MGI: 1920431; HomoloGene: 3349; GeneCards: NFATC4; OMA:NFATC4 - orthologs Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q12 Start 24,365,673 bp[1] End 24,379,604 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C3 Start 56,060,601 bp[2] End 56,071,400 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in canal of the cervix right ovary left ovary stromal cell of endometrium body of uterus left uterine tube myometrium gastric mucosa muscle layer of sigmoid colon right coronary artery
Top expressed in gastrula external carotid artery internal carotid artery genital tubercle maxillary prominence mandibular prominence ventricular zone hand calvaria abdominal wall
More reference expression data
BioGPS More reference expression data
Gene ontology Molecular function
DNA binding
DNA-binding transcription factor activity
transcription coactivator activity
transcription factor binding
RNA polymerase II cis-regulatory region sequence-specific DNA binding
DNA-binding transcription repressor activity, RNA polymerase II-specific
protein binding
DNA-binding transcription factor activity, RNA polymerase II-specific
peroxisome proliferator activated receptor binding
chromatin binding
Cellular component
transcription regulator complex
nucleus
cytoplasm
cytosol
nuclear speck
Biological process
cell differentiation
regulation of transcription, DNA-templated
cellular response to lithium ion
negative regulation of chromatin binding
cellular response to UV
negative regulation of Wnt signaling pathway
calcineurin-NFAT signaling cascade
positive regulation of apoptotic signaling pathway
negative regulation of transcription by RNA polymerase II
transcription by RNA polymerase II
negative regulation of protein binding
smooth muscle cell differentiation
transcription, DNA-templated
regulation of synaptic plasticity
negative regulation of synapse maturation
heart development
negative regulation of dendrite morphogenesis
intrinsic apoptotic signaling pathway in response to DNA damage
positive regulation of tumor necrosis factor production
branching involved in blood vessel morphogenesis
cellular respiration
positive regulation of apoptotic process
inflammatory response
muscle cell development
positive regulation of transcription by RNA polymerase II
negative regulation of pri-miRNA transcription by RNA polymerase II
cellular response to ionomycin
cytokine production
long-term memory
brain-derived neurotrophic factor receptor signaling pathway
negative regulation of neuron apoptotic process
long-term potentiation
multicellular organism development
Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl ENSG00000100968 ENSG00000285485
UniProt RefSeq (mRNA) NM_001136022 NM_001198965 NM_001198966 NM_001198967 NM_001288802 NM_004554 NM_001320043 NM_001363681 NM_001363682
RefSeq (protein) NP_001129494 NP_001185894 NP_001185895 NP_001185896 NP_001275731 NP_001306972 NP_004545 NP_001350610 NP_001350611
Location (UCSC) Chr 14: 24.37 – 24.38 Mb Chr 14: 56.06 – 56.07 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene.[5] [6]
^ a b c ENSG00000285485 GRCh38: Ensembl release 89: ENSG00000100968, ENSG00000285485 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023411 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Hoey T, Sun YL, Williamson K, Xu X (May 1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity . 2 (5): 461–72. doi:10.1016/1074-7613(95)90027-6 . PMID 7749981.
^ "Entrez Gene: NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4".
Last Update: 2023-12-03T17:52:44Z
activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene. The product of this gene is a member of the nuclear factors of activated...
Word Count : 956
Last Update: 2023-09-23T02:10:54Z
ENSG00000072736 Rel Known motif – High-throughput in vitro [590] YGGAAANH NFATC4 ENSG00000100968 Rel Known motif – High-throughput in vitro [591] YRBWWW...
Word Count : 81
Last Update: 2024-04-26T23:41:44Z
family consists of five members: NFATc1, NFATc2, NFATc3, NFATc4 , and NFAT5. NFATc1 through NFATc4 are regulated by calcium signalling, and are known as the...
Word Count : 2877
Last Update: 2023-10-30T12:11:26Z
NF-κB AP-1 Interferon regulatory factors (IRF) NFAT NFATc1 NFATc2 NFATc3 NFATc4 NFAT5 T-bet - TH1 differentiation GATA3 - TH2 differentiation RORγT - TH17...
Word Count : 2656
Last Update: 2024-06-18T16:45:48Z
"4'‑O‑methylbavachalcone inhibits succinate induced cardiomyocyte hypertrophy via the NFATc4 pathway". Experimental and Therapeutic Medicine. 25 (4): 172. doi:10.3892/etm...
Word Count : 9234