NCKAP1 information

NCKAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3P8C, 4N78
Identifiers
Aliases	NCKAP1, HEM2, NAP1, NAP125, p125Nap1, NCK associated protein 1
External IDs	OMIM: 604891; MGI: 1355333; HomoloGene: 8384; GeneCards: NCKAP1; OMA:NCKAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	183,038,858 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	80,411,724 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; frontal pole; ; skin of arm; ; Epithelium of choroid plexus; ; cerebellar vermis; ; ganglionic eminence; ; ventricular zone; ; lateral nuclear group of thalamus; ; oral cavity; ; orbitofrontal cortex;
	Top expressed in
	CA3 field; ; Region I of hippocampus proper; ; cingulate gyrus; ; dorsal striatum; ; amygdala; ; hippocampus proper; ; primary motor cortex; ; substantia nigra; ; central gray substance of midbrain; ; nucleus of stria terminalis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; protein binding;
Cellular component	integral component of membrane; cytosol; cell projection; membrane; SCAR complex; focal adhesion; plasma membrane; extracellular exosome; lamellipodium membrane; ruffle; lamellipodium; filamentous actin;
Biological process	Fc-gamma receptor signaling pathway involved in phagocytosis; positive regulation of Arp2/3 complex-mediated actin nucleation; central nervous system development; vascular endothelial growth factor receptor signaling pathway; Rac protein signal transduction; viral process; apoptotic process; positive regulation of lamellipodium assembly; positive regulation of actin filament polymerization; cell morphogenesis; cell migration; cell projection assembly; cortical actin cytoskeleton organization; neuron projection morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	10787
	50884
	ENSG00000061676
	ENSMUSG00000027002
	Q9Y2A7
	P28660
	NM_013436; NM_205842
	NM_001290745; NM_016965; NM_001355410; NM_001355411
	NP_038464; NP_995314
	NP_001277674; NP_058661; NP_001342339; NP_001342340
	Wikidata
View/Edit Human	View/Edit Mouse

Nck-associated protein 1 is a protein that in humans is encoded by the NCKAP1 gene.^[5]^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000061676 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027002 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Suzuki T, Nishiyama K, Yamamoto A, Inazawa J, Iwaki T, Yamada T, Kanazawa I, Sakaki Y (Jan 2000). "Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease". Genomics. 63 (2): 246–54. doi:10.1006/geno.1999.6053. PMID 10673335.
^ Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW (Aug 2002). "Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck". Nature. 418 (6899): 790–3. Bibcode:2002Natur.418..790E. doi:10.1038/nature00859. PMID 12181570. S2CID 4350733.
^ Matuoka K, Miki H, Takahashi K, Takenawa T (Oct 1997). "A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs". Biochemical and Biophysical Research Communications. 239 (2): 488–92. doi:10.1006/bbrc.1997.7492. PMID 9344857.
^ "Entrez Gene: NCKAP1 NCK-associated protein 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000061676 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027002 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10673335-5] Suzuki T, Nishiyama K, Yamamoto A, Inazawa J, Iwaki T, Yamada T, Kanazawa I, Sakaki Y (Jan 2000). "Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease". Genomics. 63 (2): 246–54. doi:10.1006/geno.1999.6053. PMID 10673335.

[pmid12181570-6] Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW (Aug 2002). "Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck". Nature. 418 (6899): 790–3. Bibcode:2002Natur.418..790E. doi:10.1038/nature00859. PMID 12181570. S2CID 4350733.

[pmid9344857-7] Matuoka K, Miki H, Takahashi K, Takenawa T (Oct 1997). "A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs". Biochemical and Biophysical Research Communications. 239 (2): 488–92. doi:10.1006/bbrc.1997.7492. PMID 9344857.

[entrez-8] "Entrez Gene: NCKAP1 NCK-associated protein 1".

NCKAP1 information

and 3 Related for: NCKAP1 information

NCKAP1

RAC1

ABI1