Myogel is a trade name for a human-based extracellular matrix used in cancer research to provide a 3D cell culture environment for cancer cells. Unlike other synthesized matrices such as matrigel which originated from mice sarcoma, myogel is extracted from a human benign tumor tissue called leiomyoma. Myogel was developed in Tuula Salo's lab at the University of Oulu. The idea started in 2009 by culturing cancer cells on myoma discs.[1] Later in 2015, these myoma tissues were processed following matrigel receipt, to extract a gel form called Myogel.[2] Myogel was compared with matrigel and found to be superior in term of enhancing cancer cells proliferation, migration and invasion.[2]
^Nurmenniemi, Sini; Sinikumpu, Teemu; Alahuhta, Ilkka; Salo, Sirpa; Sutinen, Meeri; Santala, Markku; Risteli, Juha; Nyberg, Pia; Salo, Tuula (September 2009). "A Novel Organotypic Model Mimics the Tumor Microenvironment". The American Journal of Pathology. 175 (3): 1281–1291. doi:10.2353/ajpath.2009.081110. PMC 2731146. PMID 19679876.
Myogel is a trade name for a human-based extracellular matrix used in cancer research to provide a 3D cell culture environment for cancer cells. Unlike...