Monopolin is a protein complex that in budding yeast is composed of the four proteins CSM1, HRR25, LRS4, and MAM1. Monopolin is required for the segregation of homologous centromeres to opposite poles of a dividing cell during anaphase I of meiosis.[1] This occurs by bridging DSN1 kinetochore proteins to sister kinetochores within the centromere to physically fuse them and allow for the microtubules to pull each homolog toward opposite mitotic spindles.[2]
^Corbett KD, Yip CK, Ee LS, Walz T, Amon A, Harrison SC (August 2010). "The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments". Cell. 142 (4): 556–67. doi:10.1016/j.cell.2010.07.017. PMC 2955198. PMID 20723757.
^Plowman, Rebecca; Singh, Namit; Tromer, Eelco C.; Payan, Angel; Duro, Eris; Spanos, Christos; Rappsilber, Juri; Snel, Berend; Kops, Geert J. P.L.; Corbett, Kevin D.; Marston, Adele L. (2019-09-01). "The molecular basis of monopolin recruitment to the kinetochore". Chromosoma. 128 (3): 331–354. doi:10.1007/s00412-019-00700-0. ISSN 1432-0886. PMC 6823300. PMID 31037469.
Monopolin is a protein complex that in budding yeast is composed of the four proteins CSM1, HRR25, LRS4, and MAM1. Monopolin is required for the segregation...
Farben and commercially marketed under the trade names, “Motolin” and “Monopolin”. Two more modern alternative fuel additives are ferrocene and methylcyclopentadienyl...
location at the center of the chromosome. Telomere Chromatid Diploid Monopolin "p + q = Solved, Being the True Story of How the Chromosome Got Its Name"...
850447 Brito IL, Monje-Casas F, Amon A (September 2010). "The Lrs4-Csm1 monopolin complex associates with kinetochores during anaphase and is required for...
(October 2016). "Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator". The EMBO Journal. 35 (19):...
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