Chemical compound
Simmerafil Other names TPN171 Legal status
N -[3-(4,5-Diethyl-6-oxo-1H -pyrimidin-2-yl)-4-propoxyphenyl]-2-(4-methylpiperazin-1-yl)acetamide
CAS Number PubChem CID Formula C 24 H 35 N 5 O 3 Molar mass 441.576 g·mol−1
Simmerafil [1] (TPN171H) is a selective PDE5 inhibitor[2] in development for the treatment of erectile dysfunction[3] and pulmonary hypertension.[4]
^ Odilov, Abdullajon; Liu, Yin; Hu, Tianwen; Jiang, Xiangrui; Suo, Jin; Tian, Guanghui; Yang, Feipu; Shen, Jingshan (19 November 2021). "Facile and Cost-Effective Route for the Synthesis of Simmerafil". Organic Process Research & Development . 25 (11): 2432–2437. doi:10.1021/acs.oprd.1c00184. ISSN 1083-6160. S2CID 244619662.
^ Qian, Hongjie; Chen, Qian; Liang, Liyu; Zou, Yang; Pu, Huahua; Xin, Liang; Song, Rong; Li, Tingting; Zhu, Huijuan; Wang, Yu; Tian, Guanghui; Shen, Jingshan; Jiang, Hualiang; Yu, Chen; Wang, Zhen; Jia, Jingying (2021). "A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects". Drug Design, Development and Therapy . 15 : 2947–2959. doi:10.2147/DDDT.S308610 . ISSN 1177-8881. PMC 8273902 . PMID 34262260.
^ "Efficacy and Safety Study of TPN171H Tablets in Erectile Dysfunction". www.clinicaltrials.gov . CTG Labs. Retrieved 9 November 2023 .
^ Zhao, Congke; Hu, Liqing; He, Xiangrong; Li, Lijun; Yin, Minghui; Tettey, Abraham Terkpertey; Wang, Yu; Shen, Jingshan; Tang, Siyuan; Wu, Chunhui; Li, Qianbin; Wang, Zhen; Li, Xiaohui (1 August 2022). "TPN171H alleviates pulmonary hypertension via inhibiting inflammation in hypoxia and monocrotaline-induced rats". Vascular Pharmacology . 145 : 107017. doi:10.1016/j.vph.2022.107017. ISSN 1537-1891. PMID 35680060. S2CID 249490064.