Mississippi Highway 388 (MS 388) is a state highway in eastern Mississippi. The route starts at the intersection of U.S. Route 45 Alternate (US 45 Alt.) and MS 852 in Brooksville, and it travels east to US 45 soon after. The route intersects MS 792 near Cliftonville, and it ends at Alabama State Route 86 (SR 86) at the Alabama–Mississippi state line. MS 388 was designated around 1957, from US 45 to a point west of the state line. The route was extended to Bigbee Valley and to the state line by 1974 and 1990, respectively.
^Mississippi Department of Transportation Planning Division (December 31, 2017). Mississippi Public Roads Selected Statistics Extent, Travel, and Designation (PDF) (Report). Mississippi Department of Transportation. p. 162. Retrieved April 7, 2020.
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