The three hallmarks of minimal change disease (seen on electron microscopy): diffuse loss of podocyte foot processes, vacuolation, and the appearance of microvilli.
Specialty
Nephrology
Minimal change disease(MCD), also known as lipoid nephrosis or nil disease, among others, is a disease affecting the kidneys which causes nephrotic syndrome.[1] Nephrotic syndrome leads to the loss of significant amounts of protein in the urine, which causes the widespread edema (soft tissue swelling) and impaired kidney function commonly experienced by those affected by the disease.[1] It is most common in children and has a peak incidence at 2 to 6 years of age.[2] MCD is responsible for 10–25% of nephrotic syndrome cases in adults.[3] It is also the most common cause of nephrotic syndrome of unclear cause (idiopathic) in children.[3]
^ abCite error: The named reference Johnson-2018 was invoked but never defined (see the help page).
^Kumar, Vinay; Abbas, Abul K.; Aster, Jon C. (2014). Robbins and Cotran pathologic basis of disease. Kumar, Vinay, 1944–, Abbas, Abul K.,, Aster, Jon C.,, Perkins, James A. (Ninth ed.). Philadelphia, PA. ISBN 9781455726134. OCLC 879416939.{{cite book}}: CS1 maint: location missing publisher (link)
^ abHogan J, Radhakrishnan J (April 2013). "The treatment of minimal change disease in adults". Journal of the American Society of Nephrology. 24 (5): 702–11. doi:10.1681/ASN.2012070734. PMID 23431071.
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Minimalchangedisease (MCD), also known as lipoid nephrosis or nil disease, among others, is a disease affecting the kidneys which causes nephrotic syndrome...
include a number of kidney diseases such as focal segmental glomerulosclerosis, membranous nephropathy, and minimalchangedisease. It may also occur as a...
number of cells is not changed. These forms usually result in the nephrotic syndrome. Causes include: Minimalchangedisease is characterised as a cause...
without any benefit. A subset of IgA nephropathy patients, who have minimalchangedisease on light microscopy and clinically have nephrotic syndrome, show...
causes such as other chronic conditions.[citation needed] Minimalchangedisease: A disease that causes unregulated activity of the immune system that...
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Minimal residual disease (MRD), also known as Molecular residual disease, is the name given to small numbers of cancer cells that remain in a person either...
uveitis after a bone marrow transplant, exacerbations of minimalchangedisease, Kimura's disease, and vitiligo. It can be used to treat dry eye syndrome...
After renal biopsy, these syndromes are commonly diagnosed as minimalchangedisease, membranoproliferative glomerulonephritis, or focal segmental glomerulosclerosis...
light intensity Minimalchangedisease, a disease of the kidney Multicentric Castleman's disease, a sub-type of Castleman's disease Magnetic chip detector...
Kidney tumour Wilms tumor Renal cell carcinoma Lupus nephritis Minimalchangedisease In nephrotic syndrome, the glomerulus has been damaged so that a...
podocyte effacement) is a hallmark of minimalchangedisease, which has therefore sometimes been called foot process disease. Disruption of the filtration slits...
syndrome, such as focal segmental glomerulosclerosis (FSGS) or minimalchangedisease (MCD). Symptoms may develop in the first few months of life (congenital...
usually because of minimal or absent gastrointestinal complaints and lack of knowledge of symptoms and diagnostic criteria. Coeliac disease is slightly more...
pulsed cyclophosphamide. Cyclophosphamide is also used to treat minimalchangedisease, severe rheumatoid arthritis, granulomatosis with polyangiitis,...
nephrotic syndrome (e.g., focal segmental glomerulosclerosis or minimalchangedisease), membranous nephropathy is known to predispose affected individuals...
Lyme disease, also known as Lyme borreliosis, is a tick-borne disease caused by species of Borrelia bacteria, transmitted by blood-feeding ticks in the...
Kawasaki disease (also known as mucocutaneous lymph node syndrome) is a syndrome of unknown cause that results in a fever and mainly affects children...
syndrome have some histo- and clinic-pathologic similarities to minimalchangedisease. Treatment for glomerular disorders is often established for specific...
The minimal important difference (MID) or minimal clinically important difference (MCID) is the smallest change in a treatment outcome that an individual...
have a secondary cause such as nephritic syndrome from FSGS or minimalchangedisease, membranoproliferative glomerulonephritis, or hepatitis C. Tubular...
microscopy. This process can be used for optical diagnosis of kidney minimal-changedisease, early breast neoplastic lesions and to spot the difference of normal...
D. (2004). "Glomerular tip lesion: A distinct entity within the minimalchangedisease/focal segmental glomerulosclerosis spectrum". Kidney International...
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