Metacaspases are members of the C14 class of cysteine proteases and thus related to caspases, orthocaspases and paracaspases.[1] The metacaspases are arginine/lysine-specific, in contrast to caspases, which are aspartate-specific.[2]
^Uren AG, O'Rourke K, Aravind LA, et al. (Oct 2000). "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma". Molecular Cell. 6 (4): 961–7. doi:10.1016/S1097-2765(05)00086-9. PMID 11090634.
^Vercammen D, van de Cotte B, De Jaeger G, et al. (Oct 2004). "Type II metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana cleave substrates after arginine and lysine". J Biol Chem. 279 (44): 45329–36. doi:10.1074/jbc.M406329200. PMID 15326173.
caspase and metacaspase sequences occurred before the divergence of eukaryotes. Biology portal Apoptosis Apoptosome Bcl-2 Emricasan Metacaspase Paracaspase...
related to caspases present in animals and slime mold, in contrast to metacaspases, which are present in plants, fungi, and "protists". The phylogenetic...
Orthocaspases is a sub-class in the C14 family of cysteine proteases. Similar to metacaspases and paracaspases, the orthocaspases cleave their protein substrates after...
cysteine protease caspase-1. In eukaryotes, a plant serpin inhibits both metacaspases and a papain-like cysteine protease. Non-inhibitory extracellular serpins...
Wickner RB (2011). "Retraction for Nemecek et al., A prion of yeast metacaspase homolog (Mca1p) detected by a genetic screen". Proc Natl Acad Sci U S...
Cysteine 464 and histidine 414 are crucial for this activity. Like metacaspases, the paracaspase cleaves substrates after an arginine residue. To date...
cell activation and MALT lymphomas. His team described the family of metacaspase proteases in plants in a paper published in 2000. In a series of papers...
Koonin EV, Dixit VM (October 2000). "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a...
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