The Mazzotti reaction, first described in 1948, is a symptom complex seen in patients after undergoing treatment of nematode infestation, particularly with the medication diethylcarbamazine (DEC). Mazzotti reactions can be life-threatening, and are characterized by fever, urticaria, swollen and tender lymph nodes, tachycardia, hypotension, arthralgias, oedema, and abdominal pain that occur within seven days of treatment of microfilariasis. The Mazzotti reaction correlates with intensity of infection; however, there are probably multiple infection intensity-dependent mechanisms responsible for mediating this complex reaction.[1]
The phenomenon is so common when DEC is used for the treatment of onchocerciasis that this drug is the basis of a skin patch test used to confirm that diagnosis. The drug patch is placed on the skin, and if the patient is infected with the microfilaria of O. volvulus, localized pruritus and urticaria are seen at the application site.[citation needed]
A case of the Mazzotti reaction has been reported after presumptive treatment of schistosomiasis and strongyloidiasis with ivermectin, praziquantel and albendazole. The patient had complete resolution of symptoms after intravenous therapy with methylprednisolone.[2]
^Francis, H; Awadzi, K; Ottesen EA (1985). "The Mazzotti reaction following treatment of onchocerciasis with diethylcarbamazine: clinical severity as a function of infection intensity". Am J Trop Med Hyg. 34 (3): 529–36. doi:10.4269/ajtmh.1985.34.529. PMID 4003668.
^Olson, Bradley G. MD; Domachowske, Joseph B. MD (May 2006). "Mazzotti Reaction After Presumptive Treatment for Schistosomiasis and Strongyloidiasis in A Liberian Refugee". Pediatric Infectious Disease Journal. 25 (5): 466–468. doi:10.1097/01.inf.0000217415.68892.0c. PMID 16645520.
The Mazzottireaction, first described in 1948, is a symptom complex seen in patients after undergoing treatment of nematode infestation, particularly...
caused by an immune response to bacteria present in the worms. The Mazzottireaction, first described in 1948, is a symptom complex seen in patients after...
(1923–2002), French actor MazzottiReaction, a symptom complex seen in tropical medicine This page lists people with the surname Mazzotti. If an internal link...
contraindicated in patients who may have onchocerciasis, due to the risk of the Mazzottireaction. Diethylcarbamazine is an inhibitor of arachidonic acid metabolism...
Carl von Rokitansky, Hermann Küster, Georges Andre Hauser Mazzottireaction – Luigi Mazzotti McArdle's Disease – Brian McArdle McCune–Albright syndrome...
debet mori". HAL (in Italian): 1–16. Mazzotti, Massimo (1998). "The Geometers of God: Mathematics and Reaction in the Kingdom of Naples" (PDF). Isis...
Press. pp. 121–161. ISBN 0-19-925636-5. Mazzotti, Masimo (1998). "The Geometers of God: Mathematics and Reaction in the Kingdom of Naples" (PDF). Isis....
businessman and Carnilinx company executive Adriano Mazzotti. The article also stated that Mazzotti donated R200,000 to the EFF for the party's electoral...
Mystery of Markawasi" (2005 ed.). Circular Times. Retrieved 9 October 2014. Mazzotti Lopez, Daniel (2001). A mochila en Perú (Backpacking in Peru) Peruvian...
3316–3318. doi:10.1021/ja710206u. PMC 2720796. PMID 18302379. Reed, S. A.; Mazzotti, A. R.; White, M. C. (2009). "A Catalytic, Brønsted Base Strategy for Intermolecular...
Mifflin. p. 28. ISBN 978-0-618-66399-6. Rice, Waddle, Miller, Crocket, Mazzotti, Percival (2011). "Recovery of native treefrogs after removal of nonindigenous...
Design. 18 (5): 3051–3061. doi:10.1021/acs.cgd.8b00201. Iggland, Martin; Mazzotti, Marco (5 October 2011). "A Population Balance Model for Chiral Resolution...
crocodiles from the cortical stratification of bone. Copeia, 332–341. Mazzotti, F. J. & Dunson, W. A. (1989). "Osmoregulation in crocodilians". American...
University of Chicago Press on behalf of The History of Science Society. Mazzotti, Massimo (25 June 2014). "Faking Galileo". LARB Quarterly Journal: Spring...
Gabriel; Rojas, Winston; Parra, Maria V.; Molina, Julio A.; Gallo, Carla; Mazzotti, Guido; Poletti, Giovanni; Hill, Kim; Hurtado, Ana M.; Labuda, Damian;...
Interior. Retrieved March 15, 2008. Fling, H.; N. Aumen; T. Armentano; F. Mazzotti (December 2004). "The Role of Flow in the Everglades Landscape". Circular...
is considerably smaller and thinner than a microfilaria. The DEC, or Mazzotti test, has been shown to have minor effects on microfilariae intensity,...
illustration of the Malfatti circles. Mazzotti, Massimo (1998), "The geometers of God: mathematics and reaction in the kingdom of Naples" (PDF), Isis...
Bibcode:2006Natur.442..188S. doi:10.1038/nature04931. PMID 16838019. S2CID 4425159. Mazzotti, S. (2004). "Variability of Near-Term Probability for the Next Great Earthquake...
; Rainwater, T. R.; Nifong, J. C.; Rosenblatt, A. E.; Heithaus, M. R.; Mazzotti, F. J. (2013). "Frugivory and seed dispersal by crocodilians: an overlooked...
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