The MasSpec Pen, or the precìso MasSpec Pen System, is a mass spectrometry (MS) based cancer detection and diagnosis system that can be used for ex vivo[1] and in vivo[2] tissue sample analysis. The system collects biological molecules from a tissue sample surface via a solid-liquid extraction mechanism and transports the molecules to a mass spectrometer for analysis. The composition of the extracted molecules can then be used to predict if the tissue sample analyzed contains cancerous cells using machine learning algorithms and statistical models. In early-stage clinical research, the MasSpec Pen system was able to distinguish various cancer tissues, including thyroid, breast, lung, and ovarian tumor tissues, from their normal counterparts with an overall accuracy of 96.3%.[1] A follow-up study in illustrating the use of the device for detection of serous ovarian carcinoma in ex vivo tissue biopsies allowed for the discrimination of normal and cancerous ovarian samples with a clinical sensitivity and specificity of 94.0% and 94.4%, respectively.[3]
^ abZhang J, Rector J, Lin JQ, Young JH, Sans M, Katta N, et al. (September 2017). "Nondestructive tissue analysis for ex vivo and in vivo cancer diagnosis using a handheld mass spectrometry system". Science Translational Medicine. 9 (406): eaan3968. doi:10.1126/scitranslmed.aan3968. PMC 5830136. PMID 28878011.
^Keating MF, Zhang J, Feider CL, Retailleau S, Reid R, Antaris A, et al. (September 2020). "Integrating the MasSpec Pen to the da Vinci Surgical System for In Vivo Tissue Analysis during a Robotic Assisted Porcine Surgery". Analytical Chemistry. 92 (17): 11535–11542. doi:10.1021/acs.analchem.0c02037. PMID 32786489. S2CID 221126047.
^Zhang, Jialing; Sans, Marta; DeHoog, Rachel J.; Garza, Kyana Y.; King, Mary E.; Feider, Clara L.; Bensussan, Alena; Keating, Michael F.; Lin, John Q.; Povilaitis, Sydney; Katta, Nitesh; Milner, Thomas E.; Yu, Wendong; Nagi, Chandandeep; Dhingra, Sadhna; Pirko, Christopher; Brahmbhatt, Kirtan A.; Van Buren, George; Carter, Stacey; Fisher, William E.; Thompson, Alastair; Grogan, Raymon H.; Suliburk, James; Eberlin, Livia S. (December 16, 2020). "Direct Molecular Analysis of In Vivo and Freshly Excised Tissues in Human Surgeries with the MasSpec Pen Technology". medRxiv 10.1101/2020.12.14.20248101v1.
The MasSpecPen, or the precìso MasSpecPen System, is a mass spectrometry (MS) based cancer detection and diagnosis system that can be used for ex vivo...
spectral database Mass spectrometry imaging Mass spectrometry software MasSpecPen Micro-arrays for mass spectrometry Nanoscale secondary ion mass spectrometry...
Foldscope (an optical microscope), the SCALE(KAS Periodic Table), the MasSpecPen (a pen that detects cancer), the glucose meter, etc. However, some scientific...
Fellow No Livia S. Eberlin Chemistry 2016–present Co-inventor of the "MasSpecPen," MacArthur "Genius" Grant and Sloan Research Fellowship, numerous other...
(2007). Encyclopaedia of Elite Forces in the Second World War. Barnsley: Pen and Sword. pp. 47–8. ISBN 978-1-84415-577-4. Joslen, H. F. (1990). Orders...
styling was reported to be based on Hyundai ix-onic concept. The ix35 was penned by Hyundai designer Cha Il-Hoei in 2007, under the guidance of former BMW...
three-box design. Like the Volkswagen Golf Mk1, its angular styling was penned at ItalDesign, by Giorgetto Giugiaro. Styling differences could be found...
Entertainment WIN, PS2 2001-10-09 Peak Performance Cave Atlus, Sega PS1 1997-01-22 PenPen TriIcelon Land Ho!, General Entertainment Infogrames North America DC 1998-11-27...
ISBN 978-0-7603-3279-5. Simons, Graham M. (2014). The Airbus A380: A History. Barnsley, UK: Pen & Sword Aviation. ISBN 978-1-78303-041-5. Wikimedia Commons has media related...
Camry hardtops to 4,630 and 4,670 mm (182.3 and 183.9 in), respectively. Penned by Osamu Shikado, the V30's design is much rounder when compared to the...
hypnotic" effect. "I'll Take You There" is the second of two Bowie–Leonard penned tracks from the sessions. A driving rock song that recalls Bowie's 1980s...
season was Perak's eighth consecutive season in the Malaysian Super League. Specs Majlis Bandaraya Ipoh (MBI) As of 28 January 2011 Note: Flags indicate national...
wheel arches gave away, the wedge-shaped aerodynamic (Cd=0.31) body was penned by Marcello Gandini. The world première of the fourth generation of the...
proposed show before a script is drafted, writers may also be assigned to pen the script and would be given credit as the series' creator(s). Pilots that...
Derived from a Calligraphy Brush Style Synthetic Hair Pen for Use in ESI/MS". Mass Spectrometry. 6 (Spec Iss): s0058. doi:10.5702/massspectrometry.s0058. PMC 5358408...
más de 70 años". El Comercio (in Spanish). Retrieved July 28, 2017. Diario Correo. "San Marcos: video muestra cómo era el examen de admisión hace más...
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