Proteins found in the urine and other secretions of many animals
Tertiary structure of a mouse major urinary protein. The protein has eight beta sheets (yellow) arranged in a beta barrel open at one end, with alpha helices (red) at both the amino- and carboxyl termini. The structure is resolved from Protein Data Bank entry 1i04. Find all instances of this protein in the PDB
Major urinary proteins (Mups), also known as α2u-globulins, are a subfamily of proteins found in abundance in the urine and other secretions of many animals. Mups provide a small range of identifying information about the donor animal, when detected by the vomeronasal organ of the receiving animal. They belong to a larger family of proteins known as lipocalins. Mups are encoded by a cluster of genes, located adjacent to each other on a single stretch of DNA, that varies greatly in number between species: from at least 21 functional genes in mice to none in humans. Mup proteins form a characteristic glove shape, encompassing a ligand-binding pocket that accommodates specific small organic chemicals.
Urinary proteins were first reported in rodents in 1932, during studies by Thomas Addis into the cause of proteinuria. They are potent human allergens and are largely responsible for a number of animal allergies, including to cats, horses and rodents. Their endogenous function within an animal is unknown but may involve regulating energy expenditure. However, as secreted proteins they play multiple roles in chemical communication between animals, functioning as pheromone transporters and stabilizers in rodents and pigs. Mups can also act as protein pheromones themselves. They have been demonstrated to promote aggression in male mice, and one specific Mup protein found in male mouse urine is sexually attractive to female mice. Mups can also function as signals between different species: mice display an instinctive fear response on the detection of Mups derived from predators such as cats and rats.
and 29 Related for: Major urinary proteins information
Majorurinaryproteins (Mups), also known as α2u-globulins, are a subfamily of proteins found in abundance in the urine and other secretions of many animals...
The human urinary system, also known as the urinary tract or renal system, consists of the kidneys, ureters, bladder, and the urethra. The purpose of...
to: Main Upgrading Programme, a housing programme in Singapore. Majorurinaryproteins Master of Urban Planning Manchester University Press Melbourne University...
calyx. Examples of the family include retinol binding proteins (RBPs) and majorurinaryproteins (Mups). RBP binds and transports retinol (vitamin A),...
Microalbuminuria List of terms associated with diabetes Protein toxicity Majorurinaryproteins UPCR "Proteinuria Causes, Symptoms, Diagnosis and Treatment"...
manifests as an allergic response to animal urine, specifically the majorurinaryproteins (Mups) of rodents, and can lead to the development of asthma. A...
1), the product of the rat Mup13 gene. Mice are fearful of these majorurinaryproteins (Mups) even when they are made in bacteria, but mutant animals that...
with high allelic diversity, such as the major histocompatibility complex in humans and the majorurinaryproteins of mice, the reference genome may differ...
fluid and urine of male mice also contains pheromones, such as majorurinaryproteins. Mice detect pheromones mainly with the vomeronasal organ (Jacobson's...
bee pheromones Insect pheromones Kairomone List of neurosteroids Majorurinaryproteins Membrane steroid receptor Osmeterium, an organ in swallowtail caterpillars...
stimulate both short and long-term learning and that darcin and other majorurinaryproteins influence the odour signature that female mice learn. She also showed...
and health. Compounds derived from the major histocompatibility complex (MHC) are bound to several urinaryproteins. The odor of a predator depresses scent-marking...
of a urinary infection. Regulating diet mainly controls urinary pH, although using medication can also control it. Diets rich in animal proteins tend...
Gi proteins are activated upon stimulation with lipophilic odorants. Go proteins are activated by nonvolatile proteins, such as the majorurinary proteins...
Mups may refer to: Majorurinaryproteins Medically unexplained physical symptoms This disambiguation page lists articles associated with the title Mups...
Suzuki; Y. Saito; S. Soeta; H. Taira; A. Suzuki (October 2006). "A majorurinaryprotein of the domestic cat regulates the production of felinine, a putative...
to empty occurs, but can hold considerably more. The Latin phrase for "urinary bladder" is vesica urinaria, and the term vesical or prefix vesico - appear...
be linked to pheromones released between conspecifics. In mice, majorurinaryproteins (Mups) have been demonstrated to promote innate aggressive behavior...
subcontinent Saharan Air Layer, or SAL Salivary lipocalin, or SAL, the pig majorurinaryprotein homologue Society of Antiquaries of London, a British historical...
MUPS may refer to: Majorurinaryproteins Medically unexplained physical symptoms the Missing and Unidentified Persons Unit, part of the California Department...
nephritis causes decreased renal expression and urinary excretion of cauxin, a majorurinaryprotein of the domestic cat". Research in Veterinary Science...
allergies. The remaining cat allergens are Fel d 2–8, with Fel d 4, a majorurinaryprotein found in the saliva of cats, occurring the most in humans among...
Saito, Y.; Soeta, S.; Taira, H.; Suzuki, A. (October 2006). "A majorurinaryprotein of the domestic cat regulates the production of felinine, a putative...
production of pure FSH or LH not "contaminated" by other proteins that may be present after urinary extraction. While some head-on studies seem not to suggest...
kidney specific proteins are expressed in the cell membrane and function as transporter proteins. The highest expressed kidney specific protein is uromodulin...
Global Information