MST1R information

MST1R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3PLS, 4FWW, 4QT8
Identifiers
Aliases	MST1R, CD136, CDw136, PTK8, RON, macrophage stimulating 1 receptor, NPCA3, SEA
External IDs	OMIM: 600168; MGI: 99614; HomoloGene: 1835; GeneCards: MST1R; OMA:MST1R - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	49,903,873 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	107,797,582 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; skin of leg; ; skin of abdomen; ; rectum; ; body of stomach; ; mucosa of ileum; ; gallbladder; ; gastric mucosa; ; upper lobe of left lung; ; testicle;
	Top expressed in
	lip; ; epithelium of stomach; ; duodenum; ; intestinal villus; ; Ileal epithelium; ; large intestine; ; colon; ; jejunum; ; mucous cell of stomach; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; macrophage colony-stimulating factor receptor activity; kinase activity; protein binding; enzyme binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; Wnt-protein binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; stress fiber; cell surface; vacuole; plasma membrane; receptor complex;
Biological process	defense response; positive regulation of protein kinase B signaling; positive regulation of MAP kinase activity; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; immune system process; single fertilization; protein phosphorylation; positive regulation of cell population proliferation; peptidyl-tyrosine phosphorylation; innate immune response; signal transduction; macrophage colony-stimulating factor signaling pathway; hepatocyte growth factor receptor signaling pathway; response to virus; Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4486
	19882
	ENSG00000164078
	ENSMUSG00000032584
	Q04912
	Q62190
	NM_001244937; NM_002447; NM_001318913
	NM_001287261; NM_009074
	NP_001231866; NP_001305842; NP_002438
	NP_001274190; NP_033100
	Wikidata
View/Edit Human	View/Edit Mouse

Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene.^[5]^[6] MST1R is also known as RON (Recepteur d'Origine Nantais) kinase, named after the French city in which it was discovered. It is related to the c-MET receptor tyrosine kinase.^[5]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164078 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032584 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Ronsin C, Muscatelli F, Mattei MG, Breathnach R (May 1993). "A novel putative receptor protein tyrosine kinase of the met family". Oncogene. 8 (5): 1195–202. PMID 8386824.
^ "Entrez Gene: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)".
^ Gaudino G, Follenzi A, Naldini L, Collesi C, Santoro M, Gallo KA, Godowski PJ, Comoglio PM (August 1994). "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP". EMBO J. 13 (15): 3524–32. doi:10.1002/j.1460-2075.1994.tb06659.x. PMC 395256. PMID 8062829.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164078 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032584 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8386824-5] Ronsin C, Muscatelli F, Mattei MG, Breathnach R (May 1993). "A novel putative receptor protein tyrosine kinase of the met family". Oncogene. 8 (5): 1195–202. PMID 8386824.

[entrez-6] "Entrez Gene: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)".

[pmid8062829-7] Gaudino G, Follenzi A, Naldini L, Collesi C, Santoro M, Gallo KA, Godowski PJ, Comoglio PM (August 1994). "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP". EMBO J. 13 (15): 3524–32. doi:10.1002/j.1460-2075.1994.tb06659.x. PMC 395256. PMID 8062829.

MST1R information

and 10 Related for: MST1R information

MST1R

Alternative splicing

Tyrosine kinase

List of human clusters of differentiation

Narnatumab

Merestinib

GRB2

Protein kinase domain

Sema domain

TRAF interacting protein