RNA polymerase II cis-regulatory region sequence-specific DNA binding
Cellular component
mediator complex
nucleus
nucleoplasm
core mediator complex
Biological process
regulation of transcription by RNA polymerase II
transcription initiation from RNA polymerase II promoter
regulation of transcription, DNA-templated
protein ubiquitination
transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
112950
80509
Ensembl
ENSG00000159479
ENSMUSG00000006392
UniProt
Q96G25
Q9D7W5
RefSeq (mRNA)
NM_201542 NM_001001653 NM_052877
NM_001290688 NM_020000 NM_173719
RefSeq (protein)
NP_001001653 NP_443109 NP_963836
NP_001277617 NP_064384 NP_776067
Location (UCSC)
Chr 1: 43.38 – 43.39 Mb
Chr 4: 118.27 – 118.27 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Mediator of RNA polymerase II transcription subunit 8 is an enzyme that in humans is encoded by the MED8 gene.[5][6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000159479 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000006392 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Brower CS, Sato S, Tomomori-Sato C, Kamura T, Pause A, Stearman R, Klausner RD, Malik S, Lane WS, Sorokina I, Roeder RG, Conaway JW, Conaway RC (Aug 2002). "Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase". Proc Natl Acad Sci U S A. 99 (16): 10353–8. Bibcode:2002PNAS...9910353B. doi:10.1073/pnas.162424199. PMC 124918. PMID 12149480.
^Jiang YW, Veschambre P, Erdjument-Bromage H, Tempst P, Conaway JW, Conaway RC, Kornberg RD (Aug 1998). "Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways". Proc Natl Acad Sci U S A. 95 (15): 8538–43. Bibcode:1998PNAS...95.8538J. doi:10.1073/pnas.95.15.8538. PMC 21111. PMID 9671713.
^Cite error: The named reference entrez was invoked but never defined (see the help page).
II transcription subunit 8 is an enzyme that in humans is encoded by the MED8 gene. This gene encodes a protein that is one of more than 20 subunits of...
although helix 1 is less conserved. MED26 has been shown to interact with MED8, Cyclin-dependent kinase 8, POLR2A, MED12 and MED28. It also acts synergistically...
P76) are strongly conserved. UBALD1 has physical association with proteins MED8, found in the nucleus, and RPL9, found in the cytoplasm. UBALD1 also associates...
Roeder RG, Conaway JW, Conaway RC (2002). "Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1...
Roeder RG, Conaway JW, Conaway RC (Aug 2002). "Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1...
CS, Sato S, Tomomori-Sato C, et al. (2002). "Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1...
Global Information
