MAP3K12 information

MAP3K12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5CEN, 5CEP, 5CEQ, 5CEO
Identifiers
Aliases	MAP3K12, DLK, MEKK12, MUK, ZPK, ZPKP1, mitogen-activated protein kinase kinase kinase 12, HP09298
External IDs	OMIM: 600447 MGI: 1346881 HomoloGene: 4592 GeneCards: MAP3K12
Gene location (Human)
Chr.	Chromosome 12 (human)
End	53,500,063 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	102,425,499 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; right uterine tube; ; anterior pituitary; ; canal of the cervix; ; cerebellar vermis; ; stromal cell of endometrium; ; pericardium; ; right coronary artery; ; tibial nerve; ; left uterine tube;
	Top expressed in
	ascending aorta; ; aortic valve; ; supraoptic nucleus; ; otic placode; ; submandibular gland; ; internal carotid artery; ; external carotid artery; ; intercostal muscle; ; seminal vesicula; ; cerebellar vermis;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; protein homodimerization activity; kinase activity; protein binding; MAP kinase kinase kinase activity; ATP binding; protein kinase binding; protein serine/threonine kinase activity; signal transducer activity; JUN kinase kinase kinase activity;
Cellular component	cytoplasm; cytosol; membrane; growth cone; plasma membrane; axon;
Biological process	intracellular signal transduction; phosphorylation; protein phosphorylation; JNK cascade; peptidyl-serine phosphorylation; protein autophosphorylation; peptidyl-threonine phosphorylation; negative regulation of motor neuron apoptotic process; MAPK cascade; positive regulation of transcription, DNA-templated; positive regulation of ERK1 and ERK2 cascade;
	Sources:Amigo / QuickGO
Orthologs
	7786
	26404
	ENSG00000139625
	ENSMUSG00000023050
	Q12852
	Q60700
	NM_001193511; NM_006301
	NM_001163643; NM_009582; NM_001358844
	NP_001180440; NP_006292
	NP_001157115; NP_033608; NP_001345773
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase 12 is an enzyme that in humans is encoded by the MAP3K12 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139625 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023050 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Reddy UR, Pleasure D (Aug 1994). "Cloning of a novel putative protein kinase having a leucine zipper domain from human brain". Biochem Biophys Res Commun. 202 (1): 613–20. doi:10.1006/bbrc.1994.1972. PMID 8037767.
^ "Entrez Gene: MAP3K12 mitogen-activated protein kinase kinase kinase 12".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139625 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023050 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8037767-5] Reddy UR, Pleasure D (Aug 1994). "Cloning of a novel putative protein kinase having a leucine zipper domain from human brain". Biochem Biophys Res Commun. 202 (1): 613–20. doi:10.1006/bbrc.1994.1972. PMID 8037767.

[entrez-6] "Entrez Gene: MAP3K12 mitogen-activated protein kinase kinase kinase 12".

MAP3K12 information

and 16 Related for: MAP3K12 information

MAP3K12

Titin

MAP kinase kinase kinase

MAP kinase kinase kinase kinase

MTOR

MTORC1

MTOR inhibitors

RAF kinase

Protein kinase A

CAMK

Wee1

Phototropin

TGF beta receptor

DLK

Protein kinase C

MTORC2