Ly6 also known as lymphocyte antigen 6 or urokinase-type plasminogen activator receptor (uPAR) is family of proteins that share a common structure but differ in their tissue expression patterns and function. Ly6 are cysteine-rich proteins that form disulfide bridges and contain a LU domain. These proteins are GPI-anchored to the cell membrane or are secreted. A total of 35 human and 61 mouse Ly6 family members have been identified.[1] Depending on which tissues they are expressed in, LY6 family members have different roles. They are expressed in various types of tissues and their expression dependent on the stage of cell differentiation.[1][2] For example, they are involved in cell proliferation, cell migration, cell–cell interactions, immune cell maturation, macrophage activation, and cytokine production.[3][1] Their overexpression or dysregulation, for example due to point mutations, is associated with tumorogenesis and autoimmune diseases.[4][5] This family was discovered in the 1970s,[6] and these proteins are still used as markers of distinct stage of leukocyte differentiation.[3]
^ abcLoughner CL, Bruford EA, McAndrews MS, Delp EE, Swamynathan S, Swamynathan SK (April 2016). "Organization, evolution and functions of the human and mouse Ly6/uPAR family genes". Human Genomics. 10 (1): 10. doi:10.1186/s40246-016-0074-2. PMC 4839075. PMID 27098205.
^Lee PY, Wang JX, Parisini E, Dascher CC, Nigrovic PA (October 2013). "Ly6 family proteins in neutrophil biology". Journal of Leukocyte Biology. 94 (4): 585–94. doi:10.1189/jlb.0113014. PMID 23543767. S2CID 1252351.
^ abKong HK, Park JH (November 2012). "Characterization and function of human Ly-6/uPAR molecules". BMB Reports. 45 (11): 595–603. doi:10.5483/bmbrep.2012.45.11.210. PMC 4133805. PMID 23186997.
^Upadhyay G (2019). "Emerging Role of Lymphocyte Antigen-6 Family of Genes in Cancer and Immune Cells". Frontiers in Immunology. 10: 819. doi:10.3389/fimmu.2019.00819. PMC 6491625. PMID 31068932.
^Sidenius N, Blasi F (June 2003). "The urokinase plasminogen activator system in cancer: recent advances and implication for prognosis and therapy". Cancer and Metastasis Reviews. 22 (2–3): 205–22. doi:10.1023/A:1023099415940. PMID 12784997. S2CID 5765336.
Ly6 also known as lymphocyte antigen 6 or urokinase-type plasminogen activator receptor (uPAR) is family of proteins that share a common structure but...
leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically...
Ly6/neurotoxin 1 is a protein in humans that is encoded by the LYNX1 gene. Alternatively spliced variants encoding different isoforms have been identified...
L83 EcoTec3 5.3 L V8 355 hp (265 kW) L86 EcoTec3 6.2 L V8 420 hp (313 kW) LY6 Vortec 6.0 L V8 360 hp (268 kW) LML Duramax 6.6 L V8 397 hp (296 kW) L5P...
linking their function to a common mechanism of 3FTx toxicity. Members of the Ly6/uPAR family are believed to be the evolutionary ancestors of the three-finger...
LY6/PLAUR Domain Containing 6B, also known under the name Cancer/Testis Antigen 116 (CTA116) and LYPD7 is encoded by the LYPD6B gene. LYPD6B is a member...
humans is encoded by the CD59 gene. It is an LU domain and belongs to the LY6/uPAR/alpha-neurotoxin protein family. CD59 attaches to host cells via a...
Ly6/PLAUR domain-containing protein 1 is a protein that in humans is encoded by the LYPD1 gene. This protein is also known as Lynx2, a member of the Lynx...
nicotinic receptors. The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is secreted into...
Ly6/PLAUR domain-containing protein 3 is a protein that in humans is encoded by the LYPD3 gene. GRCh38: Ensembl release 89: ENSG00000124466 – Ensembl...
the two most notable versions for swaps are the 5.3L LM7 and the 6.0L LQ4/LY6, all of which can be found in salvaged trucks and SUV's. Ford Windsor V8...
2003 LX3 5 June 2003 list (95942) 2003 LU5 4 June 2003 list (95943) 2003 LY6 9 June 2003 list (96009) 2004 OB6 18 July 2004 list (96026) 2004 PO27 9 August...
LY6/PLAUR domain containing 8 is a protein that in humans is encoded by the LYPD8 gene. GRCh38: Ensembl release 89: ENSG00000259823 – Ensembl, May 2017...
(help) Herberg, S.; Gert, K. R.; Schleiffer, A.; Pauli, A. (2018). "The Ly6/UPAR protein Bouncer is necessary and sufficient for species-specific fertilization"...
Kumar R, Gusev Y, Upadhyay G (2016-02-03). "Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical...
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