Chemical compound
Luzindole ATC code Legal status
In general: non-regulated
N -[2-(2-benzyl-1H -indol-3-yl)ethyl]acetamide
CAS Number 117946-91-5 Y PubChem CID ChemSpider UNII ChEBI CHEBI:131788 Y CompTox Dashboard (EPA ) DTXSID40151969 Formula C 19 H 20 N 2 O Molar mass 292.382 g·mol−1 3D model (JSmol)
O=C(NCCc2c1ccccc1[nH]c2Cc3ccccc3)C
InChI=1S/C19H20N2O/c1-14(22)20-12-11-17-16-9-5-6-10-18(16)21-19(17)13-15-7-3-2-4-8-15/h2-10,21H,11-13H2,1H3,(H,20,22)
Key:WVVXBPKOIZGVNS-UHFFFAOYSA-N
Luzindole (N-0774 ), (N -acetyl-2-benzyltryptamine ), is a drug used in scientific research to study the role of melatonin in the body. Luzindole acts as a selective melatonin receptor antagonist,[1] with approximately 11- to 25-fold greater affinity for the MT2 over the MT1 receptor.[2] [3] In animal studies, it has been observed to disrupt the circadian rhythm as well as produce antidepressant effects.[2] [4]
^ Dubocovich ML (September 1988). "Luzindole (N-0774): a novel melatonin receptor antagonist". The Journal of Pharmacology and Experimental Therapeutics . 246 (3): 902–10. PMID 2843633.
^ a b Dubocovich ML, Yun K, Al-Ghoul WM, Benloucif S, Masana MI (September 1998). "Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms". The FASEB Journal . 12 (12): 1211–20. doi:10.1096/fasebj.12.12.1211 . PMID 9737724. S2CID 566199.
^ Browning C, Beresford I, Fraser N, Giles H (March 2000). "Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors". British Journal of Pharmacology . 129 (5): 877–86. doi:10.1038/sj.bjp.0703130. PMC 1571913 . PMID 10696085.
^ Dubocovich ML, Mogilnicka E, Areso PM (July 1990). "Antidepressant-like activity of the melatonin receptor antagonist, luzindole (N-0774), in the mouse behavioral despair test". European Journal of Pharmacology . 182 (2): 313–25. doi:10.1016/0014-2999(90)90290-M. PMID 2168835.
Last Update: 2024-06-10T11:06:05Z
Luzindole (N-0774), (N-acetyl-2-benzyltryptamine), is a drug used in scientific research to study the role of melatonin in the body. Luzindole acts as...
Word Count : 459
Last Update: 2024-06-08T17:28:51Z
Piromelatine Ramelteon Tasimelteon TIK-301 (LY-156,735) Antagonists: Luzindole MT2Tooltip Melatonin receptor 2 Agonists: 2-Iodomelatonin 6-Hydroxymelatonin...
Word Count : 2894
Last Update: 2024-06-15T16:20:39Z
Piromelatine Ramelteon Tasimelteon TIK-301 (LY-156,735) Antagonists: Luzindole MT2Tooltip Melatonin receptor 2 Agonists: 2-Iodomelatonin 6-Hydroxymelatonin...
Word Count : 3461
Last Update: 2024-02-27T17:53:09Z
Piromelatine Ramelteon Tasimelteon TIK-301 (LY-156,735) Antagonists: Luzindole MT2Tooltip Melatonin receptor 2 Agonists: 2-Iodomelatonin 6-Hydroxymelatonin...
Word Count : 2894
Last Update: 2024-05-27T06:35:58Z
Piromelatine Ramelteon Tasimelteon TIK-301 (LY-156,735) Antagonists: Luzindole MT2Tooltip Melatonin receptor 2 Agonists: 2-Iodomelatonin 6-Hydroxymelatonin...
Word Count : 5735
Last Update: 2024-06-14T13:24:21Z
Piromelatine Ramelteon Tasimelteon TIK-301 (LY-156,735) Antagonists: Luzindole MT2Tooltip Melatonin receptor 2 Agonists: 2-Iodomelatonin 6-Hydroxymelatonin...
Word Count : 1110
Last Update: 2024-06-04T11:30:21Z
Piromelatine Ramelteon Tasimelteon TIK-301 (LY-156,735) Antagonists: Luzindole MT2Tooltip Melatonin receptor 2 Agonists: 2-Iodomelatonin 6-Hydroxymelatonin...
Word Count : 453
Last Update: 2023-11-06T11:14:18Z
Piromelatine Ramelteon Tasimelteon TIK-301 (LY-156,735) Antagonists: Luzindole MT2Tooltip Melatonin receptor 2 Agonists: 2-Iodomelatonin 6-Hydroxymelatonin...
Word Count : 163
Last Update: 2024-03-10T08:07:01Z
Melatonin N-Acetylserotonin Piromelatine Ramelteon Tasimelteon Afobazole Luzindole Prazosin Discovery and development of melatonin receptor agonists Reppert...
Word Count : 2654
Last Update: 2023-11-29T21:08:13Z
Piromelatine Ramelteon Tasimelteon TIK-301 (LY-156,735) Antagonists: Luzindole MT2Tooltip Melatonin receptor 2 Agonists: 2-Iodomelatonin 6-Hydroxymelatonin...
Word Count : 44
Last Update: 2023-12-03T18:49:15Z
Piromelatine Ramelteon Tasimelteon TIK-301 (LY-156,735) Antagonists: Luzindole MT2Tooltip Melatonin receptor 2 Agonists: 2-Iodomelatonin 6-Hydroxymelatonin...
Word Count : 209
Last Update: 2024-03-10T08:07:11Z
Piromelatine Ramelteon Tasimelteon TIK-301 (LY-156,735) Antagonists: Luzindole MT2Tooltip Melatonin receptor 2 Agonists: 2-Iodomelatonin 6-Hydroxymelatonin...
Word Count : 1640
Last Update: 2023-05-23T09:30:00Z
Piromelatine Ramelteon Tasimelteon TIK-301 (LY-156,735) Antagonists: Luzindole MT2Tooltip Melatonin receptor 2 Agonists: 2-Iodomelatonin 6-Hydroxymelatonin...
Word Count : 94
Last Update: 2023-01-23T00:00:10Z
Piromelatine Ramelteon Tasimelteon TIK-301 (LY-156,735) Antagonists: Luzindole MT2Tooltip Melatonin receptor 2 Agonists: 2-Iodomelatonin 6-Hydroxymelatonin...
Word Count : 47
Last Update: 2023-11-07T09:39:31Z
Piromelatine Ramelteon Tasimelteon TIK-301 (LY-156,735) Antagonists: Luzindole MT2Tooltip Melatonin receptor 2 Agonists: 2-Iodomelatonin 6-Hydroxymelatonin...
Word Count : 1006
Last Update: 2024-04-15T07:56:37Z
Piromelatine Ramelteon Tasimelteon TIK-301 (LY-156,735) Antagonists: Luzindole MT2Tooltip Melatonin receptor 2 Agonists: 2-Iodomelatonin 6-Hydroxymelatonin...
Word Count : 488
Last Update: 2023-12-12T18:43:39Z
Piromelatine Ramelteon Tasimelteon TIK-301 (LY-156,735) Antagonists: Luzindole MT2Tooltip Melatonin receptor 2 Agonists: 2-Iodomelatonin 6-Hydroxymelatonin...
Word Count : 73
Last Update: 2023-01-25T23:32:10Z
Piromelatine Ramelteon Tasimelteon TIK-301 (LY-156,735) Antagonists: Luzindole MT2Tooltip Melatonin receptor 2 Agonists: 2-Iodomelatonin 6-Hydroxymelatonin...
Word Count : 367
Last Update: 2023-01-22T15:02:25Z
Piromelatine Ramelteon Tasimelteon TIK-301 (LY-156,735) Antagonists: Luzindole MT2Tooltip Melatonin receptor 2 Agonists: 2-Iodomelatonin 6-Hydroxymelatonin...
Word Count : 162