Liarozole information

Liarozole
Names
	Preferred IUPAC name 6-[(3-Chlorophenyl)(1H-imidazol-1-yl)methyl]-1H-1,3-benzimidazole
Identifiers
CAS Number	115575-11-6 ;
3D model (JSmol)	Interactive image;
ChemSpider	54664;
IUPHAR/BPS	5210;
PubChem CID	60652;
UNII	K0Q29TGV9Y ;
CompTox Dashboard (EPA)	DTXSID9048277 ;
	InChI InChI=1S/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21) Key: UGFHIPBXIWJXNA-UHFFFAOYSA-N; InChI=1/C17H13ClN4/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15/h1-11,17H,(H,20,21) Key: UGFHIPBXIWJXNA-UHFFFAOYAV;
	SMILES C1=CC(=CC(=C1)Cl)C(C2=CC3=C(C=C2)N=CN3)N4C=CN=C4;
Properties
Chemical formula	C17H13ClN4
Molar mass	308.77 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Liarozole is a retinoic acid metabolism-blocking drug and aromatase inhibitor.^[1] Liarozole is an isomer of alprazolam, but the two compounds are completely unrelated.

^ Vahlquist, A; Blockhuys, S; Steijlen, P; Van Rossem, K; Didona, B; Blanco, D; Traupe, H (2013). "Oral liarozole in the treatment of patients with moderate/severe lamellar ichthyosis: Results of a randomized, double-blind, multinational, placebo-controlled phase II/III trial". The British Journal of Dermatology. 170 (1): 173–81. doi:10.1111/bjd.12626. PMC 4232915. PMID 24102348.

[1] Vahlquist, A; Blockhuys, S; Steijlen, P; Van Rossem, K; Didona, B; Blanco, D; Traupe, H (2013). "Oral liarozole in the treatment of patients with moderate/severe lamellar ichthyosis: Results of a randomized, double-blind, multinational, placebo-controlled phase II/III trial". The British Journal of Dermatology. 170 (1): 173–81. doi:10.1111/bjd.12626. PMC 4232915. PMID 24102348.

Liarozole information

and 28 Related for: Liarozole information

Liarozole

Vitamin A

Tretinoin

C17H13ClN4

Isotretinoin

Epidermolytic hyperkeratosis

Retinol

Talarozole

Adapalene

Trifarotene

Retinoic acid

Retinoid

Retinyl palmitate

Acitretin

Docosahexaenoic acid

Tazarotene

Etretinate

Retinoid X receptor

Retinoid receptor

Nonsteroidal

Bexarotene

Palovarotene

Retinoic acid receptor

Tamibarotene

Steroidogenesis inhibitor

Alitretinoin

Retinoic acid receptor alpha

Pelretin