Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene.[5][6][7]
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure, and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.[7] Lamin B, along with heterochromatin, is anchored to the inner surface of the nuclear membrane by the lamin B receptor.
^ abcGRCh38: Ensembl release 89: ENSG00000113368 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024590 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lin F, Worman HJ (Nov 1995). "Structural organization of the human gene (LMNB1) encoding nuclear lamin B1". Genomics. 27 (2): 230–6. doi:10.1006/geno.1995.1036. PMID 7557986.
^Wydner KL, McNeil JA, Lin F, Worman HJ, Lawrence JB (Feb 1997). "Chromosomal assignment of human nuclear envelope protein genes LMNA, LMNB1, and LBR by fluorescence in situ hybridization". Genomics. 32 (3): 474–8. doi:10.1006/geno.1996.0146. PMID 8838815.
Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene. The nuclear lamina consists of a two-dimensional matrix of proteins located next to...
lamins, the most common being laminB1 and lamin B2. They are produced from two separate genes, LMNB1 and LMNB2. Similar to prelamin A, B-type lamins...
filaments which can be categorized as either A-type (lamin A, C) or B-type (laminB1, B2) according to homology of their DNA sequences, biochemical properties...
mutations of laminB1 (LMNB1 gene) may be lethal before or at birth. Patients with classical laminopathy have mutations in the gene coding for lamin A/C (LMNA...
protease, prelamin A is referred to as lamin A. In most mammalian cells, lamin A, along with laminB1, lamin B2, and lamin C, makes up the nuclear lamina, which...
three differentially regulated genes. B-type lamins are present in every cell. B type lamins, laminB1 and B2, are expressed from the LMNB1 and LMNB2...
duplication of the LMNB1 gene, this gene takes part in the production of the laminB1 protein, which is essential for determining the nucleus' shape within the...
LAP2 plays a role in the regulation of nuclear architecture by binding laminB1 and chromosomes. This interaction is regulated by phosphorylation during...
cellular localization, including the difficult fusion to α-tubulin and LaminB1 (Figure). smURFP is named after the Smurfs, due to its light blue appearance...
caspases 3, 6, and 7, leading to cleavage of death substrates such as lamin A, laminB1, lamin B2, PARP (poly ADP ribose polymerase), and DNA-PKcs (DNA-activated...
cytoplasm where it functions in autophagy. Nuclear LC3 interacts with laminB1, and participates in the degradation of nuclear lamina. LC3 is also enriched...
Lamin B2 is a protein that in humans is encoded by the LMNB2 gene. It is the second of two type B nuclear lamins, and it is associated with laminopathies...
many targets in preparation for mitosis, including histone H1, nuclear lamins, centrosomal proteins, and microtubule associated proteins (MAPs). The subcellular...
protein complexes supported by a network of nuclear lamins. Phosphorylation of the lamins by cyclin B1-Cdk1 causes them to dissociate, compromising the structural...
PMID 15565881. Moir RD, Yoon M, Khuon S, Goldman RD (December 2000). "Nuclear lamins A and B1: different pathways of assembly during nuclear envelope formation in...
Hollinshead MS, Higbee NC, et al. (2003). "A carboxyl-terminal interaction of laminB1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation". J....
Conteh Abass Gbla Yegbeh Jalloh (wk) Ibrahim Kamara Miniru Kpaka Lansana Lamin John Lassayo George Sesay Ibrahim Sesay Alusine Turay Brian Masaba (c) Bilal...
desmin and the others, the Class IV neurofilaments and the Class V nuclear lamins. There are four major neurofilament subunits, NF-L, NF-M, NF-H and α-internexin...
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