Vaccine using an inactivated strain of Lactobacillus
Lactobacillus vaccine
Vaccine description
Target
Non-specific bacterial vaginitis, Trichomoniasis
Vaccine type
Inactivated
Clinical data
Trade names
Gynatren, SolcoTrichovac, Gynevac
Routes of administration
Intramuscular injection
ATC code
J07AX (WHO)
Lactobacillus vaccines are used in the therapy and prophylaxis of non-specific bacterial vaginitis and trichomoniasis.[1] The vaccines consist of specific inactivated strains of Lactobacilli, called "aberrant" strains in the relevant literature dating from the 1980s.[1] These strains were isolated from the vaginal secretions of patients with acute colpitis.[2] The lactobacilli in question are polymorphic, often shortened or coccoid in shape and do not produce an acidic, anti-pathogenic vaginal environment.[2] A colonization with aberrant lactobacilli has been associated with an increased susceptibility to vaginal infections and a high rate of relapse following antimicrobial treatment.[2] Intramuscular administration of inactivated aberrant lactobacilli provokes a humoral immune response.[1] The production of specific antibodies both in serum[3] and in the vaginal secretion[4] has been demonstrated. As a result of the immune stimulation, the abnormal lactobacilli are inhibited, the population of normal, rod-shaped lactobacilli can grow and exert its defense functions against pathogenic microorganisms.[1]
^ abcdCite error: The named reference Mendling1995 was invoked but never defined (see the help page).
^ abcCite error: The named reference Pavic1983 was invoked but never defined (see the help page).
^Cite error: The named reference Milovanovic1983_1 was invoked but never defined (see the help page).
^Cite error: The named reference Ruettgers1988 was invoked but never defined (see the help page).
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