dentate gyrus of hippocampal formation granule cell
visual cortex
primary visual cortex
piriform cortex
cingulate gyrus
superior frontal gyrus
lobe of cerebellum
hippocampus proper
primary motor cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
protein kinase inhibitor activity
protein binding
Cellular component
cytoplasm
integral component of membrane
neuron spine
cell junction
postsynaptic membrane
dendritic spine
plasma membrane
synapse
excitatory synapse
membrane
Schaffer collateral - CA1 synapse
glutamatergic synapse
integral component of postsynaptic density membrane
Biological process
synapse organization
postsynaptic density protein 95 clustering
regulation of synapse organization
negative regulation of protein kinase activity
cytokine-mediated signaling pathway
negative regulation of receptor signaling pathway via JAK-STAT
modulation of chemical synaptic transmission
synaptic membrane adhesion
excitatory synapse assembly
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
64101
192198
Ensembl
ENSG00000128594
ENSMUSG00000049939
UniProt
Q9HBW1
Q99PH1
RefSeq (mRNA)
NM_022143
NM_138682
RefSeq (protein)
NP_071426
NP_619623
Location (UCSC)
Chr 7: 128.03 – 128.03 Mb
Chr 6: 28.66 – 28.83 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Leucine-rich repeat-containing protein 4 is a protein that in humans is encoded by the LRRC4 gene.[5][6]
This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown.[6] Also it has been identified as a possible pathogenic gene involved in the neurogenic inflammation in rosacea.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000128594 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000049939 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wang JR, Li XL, Fan SQ, Tan C, Xiang JJ, Tang K, Wang R, Li GY (Sep 2003). "Expression of LRRC4 has the potential to decrease the growth rate and tumorigenesis of glioblastoma cell line U251". AI Zheng. 22 (9): 897–902. PMID 12969517.
repeat-containing protein 4 is a protein that in humans is encoded by the LRRC4 gene. This gene is significantly downregulated in primary brain tumors....