negative regulation of serine-type peptidase activity
negative regulation of peptidase activity
epithelial cell differentiation
hair cell differentiation
extracellular matrix organization
negative regulation of antibacterial peptide production
negative regulation of immune response
regulation of cell adhesion
negative regulation of angiogenesis
negative regulation of serine-type endopeptidase activity
regulation of T cell differentiation
cornification
regulation of timing of anagen
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
11005
72432
Ensembl
ENSG00000133710
ENSMUSG00000055561
UniProt
Q9NQ38
Q148R4
RefSeq (mRNA)
NM_001127698 NM_001127699 NM_006846
NM_001081180
RefSeq (protein)
NP_001121170 NP_001121171 NP_006837
NP_001074649
Location (UCSC)
Chr 5: 148.03 – 148.14 Mb
Chr 18: 44.1 – 44.16 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Lympho-epithelial Kazal-type-related inhibitor (LEKTI) also known as serine protease inhibitor Kazal-type 5 (SPINK5) is a protein that in humans is encoded by the SPINK5 gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000133710 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000055561 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Magert HJ, Standker L, Kreutzmann P, Zucht HD, Reinecke M, Sommerhoff CP, Fritz H, Forssmann WG (Aug 1999). "LEKTI, a novel 15-domain type of human serine proteinase inhibitor". J Biol Chem. 274 (31): 21499–502. doi:10.1074/jbc.274.31.21499. PMID 10419450.
^"Entrez Gene: SPINK5 serine peptidase inhibitor, Kazal type 5".
inhibitor (LEKTI) also known as serine protease inhibitor Kazal-type 5 (SPINK5) is a protein that in humans is encoded by the SPINK5 gene. LEKTI is a large...
serine protease inhibitor lympho-epithelial Kazal-type-related inhibitor (LEKTI). These mutations result in a dysfunctional protein that has a reduced capacity...
the activity of kallikreins via the disruption of the protease inhibitor LEKTI causes the debilitating disorder Netherton syndrome. Hyperkeratosis is an...
which encodes the serine protease inhibitor LEKTI (lymphoepithelial Kazal-type-related inhibitor). LEKTI is expressed in epithelial and mucosal surfaces...
verb noun doing person (noun form of the active participle marker -she) lekti-sha (reader person) tul no no suffix verb noun vintitul (screwdriver) ista...
activity is regulated by a number of endogenous protein inhibitors including LEKTI, SPINK6, elafin and alpha-2-Macroglobulin-like 1. Both Zn2+ and Cu2+ ions...
serine protease inhibitor lympho-epithelial Kazal-type-related inhibitor (LEKTI) and also micro-environmental pH; and single-metal-ion inhibitors of KLKs...