La-related protein 4 is a protein that in humans is encoded by the LARP4 gene.[4][5] LARP4 is an RNA-binding protein which consists of a La motif (LaM), RNA recognition motif (RRM) and a putative PABP binding motif. It has been shown that LARP4 is involved in mRNA stability.[6]
LARP4 is known to regulate cancer cell migration and invasion by altering cell shape.[7] It is also reported to be a glioma tumor suppressor.[8]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000023025 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
^"Entrez Gene: LARP4 La ribonucleoprotein domain family, member 4".
^Yang R, Gaidamakov SA, Xie J, Lee J, Martino L, Kozlov G, Crawford AK, Russo AN, Conte MR, Gehring K, Maraia RJ (February 2011). "La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability". Molecular and Cellular Biology. 31 (3): 542–56. doi:10.1128/MCB.01162-10. PMC 3028612. PMID 21098120.
^Seetharaman S, Flemyng E, Shen J, Conte MR, Ridley AJ (November 2016). "The RNA-binding protein LARP4 regulates cancer cell migration and invasion". Cytoskeleton. 73 (11): 680–690. doi:10.1002/cm.21336. PMC 5111583. PMID 27615744.
^Koso H, Yi H, Sheridan P, Miyano S, Ino Y, Todo T, Watanabe S (April 2016). "Identification of RNA-Binding Protein LARP4B as a Tumor Suppressor in Glioma". Cancer Research. 76 (8): 2254–64. doi:10.1158/0008-5472.CAN-15-2308. PMID 26933087.
La-related protein 4 is a protein that in humans is encoded by the LARP4 gene. LARP4 is an RNA-binding protein which consists of a La motif (LaM), RNA...
1 LARP1 LARP1 La-related protein 1 LARP1B LARP1B La-related protein 1b LARP4 La-Related protein 4 La Ribonucleoprotein Domain Family Member 4 LARP4B...