negative regulation of protein homooligomerization
neutrophil degranulation
chaperone-mediated autophagy
protein targeting to lysosome involved in chaperone-mediated autophagy
autophagosome maturation
lysosomal protein catabolic process
establishment of protein localization to organelle
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3920
16784
Ensembl
ENSG00000005893
ENSMUSG00000016534
UniProt
P13473
P17047
RefSeq (mRNA)
NM_013995 NM_001122606 NM_002294
NM_001017959 NM_001290485 NM_010685
RefSeq (protein)
NP_001116078 NP_002285 NP_054701
NP_001017959 NP_001277414 NP_034815
Location (UCSC)
Chr X: 120.43 – 120.47 Mb
Chr X: 37.49 – 37.55 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Lysosome-associated membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins.
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of the gene produces three variants - LAMP-2A, LAMP-2B and LAMP-2C.[5] LAMP-2A is the receptor for chaperone-mediated autophagy. Recently it has been determined that antibodies against LAMP-2 account for a fraction of patients who get a serious kidney disease termed focal necrotizing glomerulonephritis.
LAMP-2B is associated with Danon disease.
^ abcGRCh38: Ensembl release 89: ENSG00000005893 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000016534 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: LAMP2 lysosomal-associated membrane protein 2".
membrane protein 2 (LAMP2), also known as CD107b (Cluster of Differentiation 107b) and Mac-3, is a human gene. Its protein, LAMP2, is one of the lysosome-associated...
LAMP2, which results in a change to the normal protein structure. While the function of the LAMP2 gene is not well understood, it is known that LAMP2...
expression of LAMP1 and LAMP2 glycoproteins are linked, as deficiencies in LAMP1 gene will lead to increased expression of LAMP2 glycoproteins. The two...
Reconnaissance Orbiter Lysosome-associated membrane glycoprotein, including LAMP1, LAMP2, LAMP3 Light Airborne Multi-Purpose System (LAMPS), a United States Navy...
form. Also, Fanconi-Bickel syndrome (gene SLC2A2) and Danon disease (gene LAMP2) were declassed as GSDs due to being defects of transport proteins rather...
for mitochondrial biogenesis, maintenance and function) along with low LAMP2 protein level and lysosome number (both important for mitophagy: the degradation...
different parts of the chromosome: Danon disease is caused by a mutation of the LAMP2 gene; XMEA is caused by mutations of the VMA21 gene. These gene mutations...
Membrane Protein 1 (LAMP1) CD107b Lysosome-associated Membrane Protein 2 (LAMP2) CD108 Semaphorin-7A, encoded by SEMA7A gene; also known as the John-Milton-Hagen...
Endoplasmic reticulum : missense mutations in the N-terminus G35D, L39R II LAMP2 positive granules and ER D78V, G84R, C116R, G118E, A173D, W292G III Lysosomal...
membrane glycoprotein) is a member of the LAMP family along with LAMP1 and LAMP2, these proteins make up the members of the glycoconjugate coat present on...
and the implementation of a Land Administration and Management Project (LAMP2) which received a 'very good' rating from the World Bank (WB) and Australian...
VPS35 downregulation by RNAi allows DMT1 to associate more closely with LAMP2-positive structures, increasing iron concentration in lysosomes and impairing...
localized in lysosomes, co-localizing with lysosomal markers LAMP1 and LAMP2 in lysosomes in separate studies. PLD3 was identified as a protein in insulin...