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Figure 1. A fraction of receptor not bound to ligand in solution is captured by the ligand coated solid phase and subsequently labelled with a fluorescent secondary antibody.
A kinetic exclusion assay (KinExA) is a type of bioassay in which a solution containing receptor, ligand, and receptor-ligand complex is briefly exposed to additional ligand immobilized on a solid phase.[1][2]
^Blake, Robert C.; Pavlov, Andrey R.; Blake, Diane A. (1999). "Automated Kinetic Exclusion Assays to Quantify Protein Binding Interactions in Homogeneous Solution". Analytical Biochemistry. 272 (2): 123–134. doi:10.1006/abio.1999.4176. PMID 10415080.
^Darling, Ryan J.; Brault, Pierre-Alexandre (2004). "Kinetic Exclusion Assay Technology: Characterization of Molecular Interactions". ASSAY and Drug Development Technologies. 2 (6): 647–657. doi:10.1089/adt.2004.2.647. ISSN 1540-658X. PMID 15674023.
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