Intravitreal administration delivers substances directly into the anterior chamber of eyeball.
Specialty
ophthalmology
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An intracameral injection is usually of an antibiotic into the anterior chamber of the eyeball to prevent endophthalmitis caused by an infection of the eye that can occur after cataract surgery. The Food and Drug Administration (FDA) has not approved antibiotics for this use and it is considered 'off-label'. Concerns about this procedure contributing to increasing numbers of antibiotic resistant bacteria have been expressed.[1]
In the UK, Aprokam cefuroxime has been approved for use in intracameral injections.[2] Intracameral injection of recombinant tissue plasminogen activator (r-TPA) has been found to be effective in treating the development of fibrin intraocularly after the development of endophthalmitis.[3]
^Kent C. "Antibiotics & cataract surgery: new frontiers". Review of Ophthalmology. Retrieved 3 April 2017.
^"Aprokam cefuroxime 50mg powder for solution for injection - Summary of Product Characteristics (SPC) - (eMC)". Retrieved 3 April 2017.
^Wu TT, Wang HH (January 2009). "Intracameral recombinant tissue plasminogen activator for the treatment of severe fibrin reaction in endophthalmitis". Eye. 23 (1): 101–107. doi:10.1038/sj.eye.6702984. PMID 17901882.
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