Interstate 22 (I-22) is a 202.22-mile-long (325.44 km) Interstate Highway in the US states of Mississippi and Alabama, connecting I-269 near Byhalia, Mississippi, to I-65 near Birmingham, Alabama. I-22 is also Corridor X of the Appalachian Development Highway System (ADHS). Designated in 2012, I-22 follows the route of older U.S. Route 78 (US 78) and is concurrent with the route for all but its eastern most 11 miles (18 km). The freeway mainly spans rural areas and passes numerous small towns along its route, including Fulton, Tupelo, New Albany, and Holly Springs in Mississippi and Jasper, Winfield, and Hamilton in Alabama.
I-22 was upgraded to Interstate Highway standards to close a gap in the Interstate Highway System, allowing for more direct connections between cities in the southeast with cities in the central part of the country. I-22 indirectly connects I-240, I-40, I-55, and I-69 in the Memphis metropolitan area via US 78 and I-269, and indirectly connects with I-459, I-20, and I-59 in the Birmingham metropolitan area via I-65.
^Starks, Edward (January 27, 2022). "Table 1: Main Routes of the Dwight D. Eisenhower National System of Interstate and Defense Highways". FHWA Route Log and Finder List. Federal Highway Administration. Retrieved March 10, 2023.
^Special Committee on U.S. Route Numbering (November 16, 2012). "SCOH Report from Special Committee on U.S. Route Numbering Annual Meeting" (PDF) (Report). Washington, DC: American Association of State Highway and Transportation Officials. p. 2. Archived from the original (PDF) on June 3, 2019. Retrieved September 23, 2014.
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