International Subarachnoid Aneurysm Trial information
The International Subarachnoid Aneurysm Trial (ISAT) was a large multicentre, prospective randomised clinical medical trial, comparing the safety and efficacy of endovascular coil treatment and surgical clipping for the treatment of brain aneurysms. The study began in 1994. The first results were published in The Lancet in 2002, and the 10 year data were published again in The Lancet in early September 2005. 2,143 study participants were mostly drawn from U.K. hospitals with the rest drawn from North American and European hospitals.
The study found better results with endovascular coil treatment compared to surgical clipping, however subsequent studies have questioned this conclusion.[1] The study was criticised by many clinicians and not well accepted by surgeons.[2]: 206–07 Primary criticisms were related to the study's patient population's generalisability to the wider population, and the long-term prognosis of coil embolisation.[3]
^AJNR Am J Neuroradiol. 2005 Feb;26(2):367-72.
^Michael Forsting, Isabel Wanke, Intracranial Vascular Malformations and Aneurysms: From Diagnostic Work-Up to Endovascular Therapy, Springer 2008, ISBN 3-540-32919-6.
^Michael J. Alexander, Robert Friedrich Spetzler, Pediatric neurovascular disease: surgical, endovascular, and medical management, Thieme: 2006, ISBN 1-58890-368-0, page 145.
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randomised control trialInternationalSubarachnoidAneurysmTrial appears to indicate a higher rate of recurrence when intracerebral aneurysms are treated using...
"Retreatment of ruptured cerebral aneurysms in patients randomized by coiling or clipping in the InternationalSubarachnoidAneurysmTrial (ISAT)". Stroke. 38 (5):...
ISAT can stand for: InternationalSubarachnoidAneurysmTrial Illinois Standards Achievement Test Idaho Standards Achievement Test In Situ Adaptive Tabulation...
matrix coils work better than bare platinum coils. The InternationalSubarachnoidAneurysmTrial tested the efficacy of endovascular coiling against the...
of balance Speech problems Double vision For a ruptured aneurysm, symptoms of a subarachnoid hemorrhage may present: Severe headaches Loss of vision Double...
third type of brain hemorrhage, known as a subarachnoid hemorrhage (SAH), causes bleeding into the subarachnoid space between the arachnoid mater and the...
Dissecting aneurysms of the vertebral artery constitute 4% of all cerebral aneurysms, and are hence a relatively rare but important cause of subarachnoid hemorrhage...
arteriovenous malformation and an intracranial aneurysm, which can cause intraparenchymal or subarachnoid hemorrhage. In addition to neurological impairment...
the cerebrospinal fluid is produced and circulates through towards the subarachnoid space. It can result from physical trauma or from hemorrhagic stroke...
subarachnoid space around the brain. The most common cause of a subarachnoid hemorrhage is an aneurysm rupture due to the weakened blood vessel walls and increased...
Retrieved 2019-11-03. International Study of Unruptured Intracranial Aneurysms Investigators (1998-12-10). "Unruptured Intracranial Aneurysms — Risk of Rupture...
cause aortic root aneurysms, and aneurysms in the circle of Willis cerebral arteries, which if they rupture, can cause a subarachnoid hemorrhage. Diagnosis...
(October 1, 1966). "Report on the cooperative study of intracranial aneurysms and subarachnoid hemorrhage. Section VI. Arteriovenous malformations. An analysis...
cerebrovascular FMD include TIA, ischemic stroke, Horner syndrome, or subarachnoid hemorrhage. Patients with mesenteric, or intestinal, FMD may experience...
body or difficulty speaking. If the bleeding occurs into the subarachnoid space (subarachnoid hemorrhage), there is usually a severe, sudden headache and...
Davie Cooper Scottish Aneurysm Study Group was founded as part of Graham Teasdale's research into the familial risk of Subarachnoid Haemorrhage (SAH) which...
alternative causes of headache and neurological abnormalities, such as a subarachnoid hemorrhage, have been excluded. There are various neuroimaging investigations...
Puri AS, et al. (May 2022). "Transvascular in vivo microscopy of the subarachnoid space". Journal of Neurointerventional Surgery. 14 (5): 420–428. doi:10...
emerging for other indications such as acute ischemic stroke and aneurysmal subarachnoid hemorrhage. Treatment options for full-term and preterm babies who develop...
important to realize that headaches that begin during orgasm may be due to a subarachnoid hemorrhage, so serious causes must be ruled out first. These headaches...
spinal cord and peripheral nerves Intracerebral hemorrhage, such as subarachnoid hemorrhage, interdepartmental, and intracellular hemorrhages Some forms...
mater. Between the arachnoid mater and the pia mater is the subarachnoid space and subarachnoid cisterns, which contain the cerebrospinal fluid. The outermost...
remainder are due to hemorrhage, either intracerebral hemorrhage or subarachnoid hemorrhage. The incidence of stroke rises progressively with increasing...
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