Internalins are surface proteins found on Listeria monocytogenes. They exist in two known forms, InlA and InlB. They are used by the bacteria to invade mammalian cells via cadherins transmembrane proteins and Met receptors respectively. The exact role of these proteins and their invasiveness in vivo is not completely understood. In cultured cells, InlA is necessary to facilitate Listeria entry into human epithelial cells, while InlB is necessary for Listeria internalisation in several other cell types, including hepatocytes, fibroblasts, and epithelioid cells.[1] Internalins are mainly surface-exposed virulence
factors present in a number of Gram-positive bacteria whose role ranges from recognition of cellular receptors to aid in pathogen entry to escape from autophagy.[2]
Listeria poses a particular threat to pregnant women because of its ability to cross the placental blood barrier through the combined binding of both InIA and InIB to host cells. Research has shown that only the combined binding of these two virulence factors allows the bacteria to cross that barrier. This is not the case in mice and guinea pigs whose cells only have affinity for InIB in mice and InIA in guinea pigs.[3] InlB blocks the action of cytotoxic T-cells and extents the infected cell lifespan.[4]
^Lecuit M, Ohayon H, Braun L, Mengaud J, Cossart P (1997). "Internalin of Listeria monocytogenes with an intact leucine-rich repeat region is sufficient to promote internalization". Infect. Immun. 65 (12): 5309–19. doi:10.1128/iai.65.12.5309-5319.1997. PMC 175764. PMID 9393831.
^Structure of Internalin InlK from the Human
Pathogen Listeria monocytogenes
^Babinet, Charles, et al. "Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis." Nature 455.7216 (2008): 1114+. Academic OneFile. Web. 4 Dec. 2014.
^Claire Maudet; Marouane Kheloufi; Sylvain Levallois; Julien Gaillard; Lei Huang; Charlotte Gaultier; Yu-Huan Tsai; Olivier Disson; Marc Lecuit (2022). "Bacterial inhibition of Fas-mediated killing promotes neuroinvasion and persistence". Nature. 603 (7903): 900–906. Bibcode:2022Natur.603..900M. doi:10.1038/s41586-022-04505-7. PMID 35296858. S2CID 247497780.
Internalins are surface proteins found on Listeria monocytogenes. They exist in two known forms, InlA and InlB. They are used by the bacteria to invade...
adhesins are the internalins. Listeria uses internalin A and B to bind to cellular receptors. Internalin A binds to E-cadherin, while internalin B binds to...
developed a chemical mechanism to do so. This involves a bacterial protein internalin (InlA/InlB), which attaches to a protein on the intestinal cell membrane...
(including streptolysin). Examples for Listeria monocytogenes include internalin A, internalin B, listeriolysin O, and actA, all of which are used to help colonize...
Investigating the Potentially Expanded Target Repertoire of Murinized Internalin of Listeria Monocytogenes Following graduation, he joined the Council...
approximations, a method for approximate Bayesian inference InlA, one form of the Internalin surface protein found on Listeria monocytogenes Iraq National Library...
which is specific for Listeria ivanovii, encodes two small, secreted internalins and contributes to virulence in mice". Molecular Microbiology. 30 (2):...
by Cossart's lab of the interaction between L. monocytogenes' protein, internalin, and its cell receptor, E-cadherin, was the first such study that successfully...