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Inosine monophosphate synthase information


ATIC
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesATIC, AICAR, AICARFT, HEL-S-70p, IMPCHASE, PURH, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
External IDsOMIM: 601731; MGI: 1351352; HomoloGene: 2983; GeneCards: ATIC; OMA:ATIC - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004044

NM_026195

RefSeq (protein)

NP_004035

NP_080471

Location (UCSC)Chr 2: 215.31 – 215.35 MbChr 1: 71.6 – 71.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bifunctional purine biosynthesis protein PURH is a protein that in humans is encoded by the ATIC gene.[5][6][7]

ATIC encodes an enzyme which generates inosine monophosphate from aminoimidazole carboxamide ribonucleotide.

It has two functions:

  • EC 2.1.2.3 - 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
  • EC 3.5.4.10 - IMP cyclohydrolase
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138363 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026192 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Rayl EA, Moroson BA, Beardsley GP (Mar 1996). "The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping". J Biol Chem. 271 (4): 2225–33. doi:10.1074/jbc.271.4.2225. PMID 8567683.
  6. ^ Sugita T, Aya H, Ueno M, Ishizuka T, Kawashima K (Nov 1997). "Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase". J Biochem. 122 (2): 309–13. doi:10.1093/oxfordjournals.jbchem.a021754. PMID 9378707.
  7. ^ "Entrez Gene: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase".

and 26 Related for: Inosine monophosphate synthase information

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Inosine monophosphate synthase

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encoded by the ATIC gene. ATIC encodes an enzyme which generates inosine monophosphate from aminoimidazole carboxamide ribonucleotide. It has two functions:...

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Adenosine monophosphate

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performed in aerobes by the ATP synthase during oxidative phosphorylation) AMP can be converted into inosine monophosphate by the enzyme myoadenylate deaminase...

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Purine metabolism

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nucleotide inosine monophosphate (IMP), which is the first compound in the pathway to have a completely formed purine ring system. Inosine monophosphate is synthesized...

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AICA ribonucleotide

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is an intermediate in the generation of inosine monophosphate. AICAR is an analog of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent...

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synthase. Defective UMP synthase can result in orotic aciduria, a metabolic disorder. In a study, gerbils fed a combination of uridine monophosphate,...

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ATIC

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Air and Space Intelligence Center ATIC, a gene which codes inosine monophosphate synthase Advanced Thin Ionization Calorimeter, a balloon-borne experiment...

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Nucleotide

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form the common purine precursor inosine monophosphate (IMP). Inosine monophosphate is converted to adenosine monophosphate in two steps. First, GTP hydrolysis...

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Adenylosuccinate synthase

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catalysing the guanosine triphosphate (GTP)-dependent conversion of inosine monophosphate (IMP) and aspartic acid to guanosine diphosphate (GDP), phosphate...

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AICAR

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Business School, Matheran, India Acadesine AICA ribonucleotide Inosine monophosphate synthase, an enzyme This disambiguation page lists articles associated...

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Adenylosuccinate

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interconversion of purine nucleotides inosine monophosphate (IMP) and adenosine monophosphate (AMP). The enzyme adenylosuccinate synthase carries out the reaction...

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Nucleic acid metabolism

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classified as purines. In purine synthesis, PRPP is turned into inosine monophosphate, or IMP. Production of IMP from PRPP requires glutamine, glycine...

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Adenosine diphosphate

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can be interconverted to adenosine triphosphate (ATP) and adenosine monophosphate (AMP). ATP contains one more phosphate group than does ADP. AMP contains...

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Glycineamide ribonucleotide

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biochemical intermediate in the formation of purine nucleotides via inosine-5-monophosphate, and hence is a building block for DNA and RNA. The vitamins thiamine...

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Biosynthesis

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final step involves the enzyme IMP synthase, which performs the purine ring closure and forms the inosine monophosphate intermediate. Other DNA and RNA nucleotide...

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List of biomolecules

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Actinomycin D Adenine Adenosmeme Adenosine diphosphate (ADP) Adenosine monophosphate (AMP) Adenosine triphosphate (ATP) Adenylate cyclase Adiponectin Adonitol...

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Purinosome

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biosynthetic pathway converting phosphoribosyl pyrophosphate to inosine monophosphate: The enzymes of the multi-step de novo purine biosynthesis pathway...

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Phosphoribosylamine

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biochemical intermediate in the formation of purine nucleotides via inosine-5-monophosphate, and hence is a building block for DNA and RNA. The vitamins thiamine...

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Phosphoribosyl pyrophosphate

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biochemical intermediate in the formation of purine nucleotides via inosine-5-monophosphate, as well as in pyrimidine nucleotide formation. Hence it is a building...

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Nucleoside triphosphate

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assembled directly onto PRPP. This results in a nucleotide called inosine monophosphate (IMP). IMP is then converted to either a precursor to AMP or GMP...

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CBS domain

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beta synthase, one of the proteins it is found in. CBS domains are also found in a wide variety of other proteins such as inosine monophosphate dehydrogenase...

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Ribavirin

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action. The enzyme inosine triphosphate pyrophosphatase (ITPase) dephosphorylates ribavirin triphosphate in vitro to ribavirin monophosphate, and ITPase reduced...

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Uracil

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synthesize uracil, in the form of uridine monophosphate (UMP), by decarboxylating orotidine 5'-monophosphate (orotidylic acid). In humans this decarboxylation...

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Webe Kadima

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Acta. W. Kadima and M. Zador: Kinetics on interaction of Pd(en)Cl2 with inosine in chloride containing aqueous solutions. Jan 1983, Inorganica Chimica...

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Metabolism

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Both adenine and guanine are made from the precursor nucleoside inosine monophosphate, which is synthesized using atoms from the amino acids glycine,...

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Mercaptopurine

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and guanine for the enzyme HGPRT and is itself converted to thio inosine monophosphate (TIMP). TIMP inhibits several chemical reactions involving inosinic...

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Phosphoribosylglycinamide formyltransferase

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pathway. This pathway creates inosine monophosphate (IMP), a precursor to adenosine monophosphate (AMP) and guanosine monophosphate (GMP). AMP is a building...

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