Global InformationIbpB thermometer information
| IbpB thermometer | |
|---|---|
 Conserved secondary structure of the IbpB thermometer | |
| Identifiers | |
| Symbol | ibpB 5' UTR |
| Other data | |
| RNA type | RNA thermometer |
| Domain(s) | E. coli |
| PDB structures | PDBe |
The IbpB thermometer is an RNA thermometer element found in the ibpAB operon.[1] The operon contains two heat-shock genes, encoding inclusion body binding proteins A and B (IbpA/B), and is the most drastically upregulated operon under heat-shock in Escherichia coli.[2]
IbpA is regulated by a ROSE element found in its 5' UTR,[3][4] while IbpB has its own heat-sensitive cis-regulatory element. The activity of this thermoregulator was confirmed in vitro but was not found in vivo, suggesting more complicated operon regulation exists in bacterial cells.[1]
- ^ a b Gaubig LC, Waldminghaus T, Narberhaus F (January 2011). "Multiple layers of control govern expression of the Escherichia coli ibpAB heat-shock operon". Microbiology. 157 (Pt 1): 66–76. doi:10.1099/mic.0.043802-0. PMID 20864473.
- ^ Richmond CS, Glasner JD, Mau R, Jin H, Blattner FR (October 1999). "Genome-wide expression profiling in Escherichia coli K–12". Nucleic Acids Research. 27 (19): 3821–3835. doi:10.1093/nar/27.19.3821. PMC 148645. PMID 10481021.
- ^ Waldminghaus T, Gaubig LC, Klinkert B, Narberhaus F (Sep–Oct 2009). "The Escherichia coli ibpA thermometer is comprised of stable and unstable structural elements". RNA Biology. 6 (4): 455–463. doi:10.4161/rna.6.4.9014. PMID 19535917.
- ^ Waldminghaus T, Fippinger A, Alfsmann J, Narberhaus F (December 2005). "RNA thermometers are common in alpha- and gamma-proteobacteria". Biological Chemistry. 386 (12): 1279–1286. doi:10.1515/BC.2005.145. PMID 16336122.