Global InformationIMP cyclohydrolase information
| IMP cyclohydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.5.4.10 | ||||||||
| CAS no. | 9013-81-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| IMP cyclohydrolase-like protein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of puro from methanothermobacter thermoautotrophicus | |||||||||
| Identifiers | |||||||||
| Symbol | IMP_cyclohyd | ||||||||
| Pfam | PF07826 | ||||||||
| InterPro | IPR020600 | ||||||||
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In enzymology, an IMP cyclohydrolase (EC 3.5.4.10) is an enzyme that catalyzes the chemical reaction
- IMP + H2O 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
Thus, the two substrates of this enzyme are IMP and H2O, whereas its product is 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is IMP 1,2-hydrolase (decyclizing). Other names in common use include inosinicase, and inosinate cyclohydrolase. This enzyme catalyses the cyclisation of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP, a reaction which is important in de novo purine biosynthesis in archaeal species.[1]
- ^ Graupner M, Xu H, White RH (March 2002). "New class of IMP cyclohydrolases in Methanococcus jannaschii". J. Bacteriol. 184 (5): 1471–3. doi:10.1128/jb.184.5.1471-1473.2002. PMC 134845. PMID 11844782.