Hydroacylation is a type of organic reaction in which an electron-rich[1] unsaturated hydrocarbon inserts into a formyl C-H bond. With alkenes, the product is a ketone:
RCHO + CH2=CHR' → RC(O)CH2CH2R'
With an alkyne instead, the reaction produces an α,β-unsaturated ketone.[2]
The reaction requires a metal catalyst or a radical initiator.[1] It is almost invariably practiced as an intramolecular reaction using homogeneous catalysts, often based on rhodium phosphines.
Hydroacylation is a type of organic reaction in which an electron-rich unsaturated hydrocarbon inserts into a formyl C-H bond. With alkenes, the product...
significant role in the trafficking, targeting, and function of Wnt proteins. Hydroacylation Acetyl Ketene Brown, William H.; Iverson, Brent L.; Anslyn, Eric V.;...
dienophile component, giving a pyran or related compound. Hydroacylation Ketone In hydroacylation an aldehyde is added over an unsaturated bond to form a...
Irvine (UCI). Early highlights of research at UCI include catalytic hydroacylation and the activation of aldehyde C-H bonds. Dong demonstrated that rhodium...
peroxide Cyclopropanation cyclopropanes addition of carbenes or carbenoids Hydroacylation ketones oxidative addition / reductive elimination by metal catalyst...
H2. In 1999, Chul-Ho Jun and Hyuk Lee reported the first example of hydroacylation through shuttle catalysis. In this example, 3-methyl-2-aminopyridine...
aldol condensation. Madelung synthesis of indoles Smiles rearrangement Hydroacylation is almost invariably practiced intramolecularly to produce ketones....
initiation of expression for certain mitochondrial genes. Hydroformylation Hydroacylation Olah, George A.; Ohannesian, Lena.; Arvanaghi, Massoud. (1987). "Formylating...
Hydrovinylation (including hydroarylation and olefin dimerization and others) Hydroacylation Hydroformylation (refers specifically to the addition of CHO and H using...
ortho-alkylation of aromatic ketones, alkyl aldehyde isomerization, hydroacylation, and the dehydrogenation of alkoxy silanes to generate silyl enol ethers...
developed in asymmetric hydrogenation. Other areas of research included hydroacylation catalysis and the development of ligands that mimic the spectroscopic...
produced from aldehydes by C-H oxidative addition. This reaction underpins hydroacylation. In a related reaction, metal carbonyl anions are acylated by acyl chlorides:...
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