Horace Gilbert Smithy Jr. (July 19, 1914 – October 28, 1948) was an American cardiac surgeon who in 1948 performed the first successful mitral valve repair (mitral valvulotomy) since the 1920s. Smithy's work was complicated because it predated heart-lung machines or open heart surgery. Though his procedure did not become a definitive treatment for valvular heart disease, he introduced the technique of injecting novocaine into the heart to avoid arrhythmias during surgery, and he showed that it was feasible to access and operate on the heart's valves.
A graduate of the University of Virginia School of Medicine, Smithy completed a surgical residency in Charleston, South Carolina, and then practiced surgery at Roper Hospital in Charleston. He also began working with a colleague in a dog laboratory to devise a valvulotomy (surgical treatment for diseased heart valves). Smithy's interest in heart valve dysfunction was also personal; he suffered from narrowing of the aortic valve related to rheumatic heart disease.
As Smithy began to operate on a series of patients with heart valve disease, he started to correspond with eminent heart surgeon Alfred Blalock, hoping that ultimately Blalock would agree to perform a valvulotomy on him. Smithy had a patient come to Baltimore so that Blalock and Smithy could operate on the patient together. When that patient died on the operating table, Blalock refused to be involved with further surgery of that type. Smithy died at Roper Hospital of cardiac asthma, pneumonia and another attack of rheumatic fever. His death came a few months after he performed his first valvulotomy; he had been unable to convince anyone to perform the surgery on him.
Horace Gilbert Smithy Jr. (July 19, 1914 – October 28, 1948) was an American cardiac surgeon who in 1948 performed the first successful mitral valve repair...
operations for mitral valve stenosis resulting from rheumatic fever. HoraceSmithy of Charlotte used a valvulotome to remove a portion of a patient's mitral...
successful operations for mitral stenosis resulting from rheumatic fever. HoraceSmithy (1914–1948) revived an operation due to Dr Dwight Harken of the Peter...
the way for the development of hybridomas and monoclonal antibodies". HoraceSmithy 1938 American cardiac surgeon who performed the first successful mitral...
the New York Yankees from 1939 to 1946, in New York City (d. 2005); HoraceSmithy, American surgeon, performed the first heart valve operation, in Norfolk...
a senior role. Andrew Lancel, as Neil Manson, and Alex Walkinshaw, as "Smithy", also appeared in the series finale. The character of D.I. Roy Galloway...
known as knockout mice. He shared the prize with Martin Evans and Oliver Smithies. He is currently Distinguished Professor of Human Genetics and Biology...
still Yesterday's Man", The Times, London, 5 September 1972, p. 12. Bill Smithies; Peter Fiddick. Enoch Powell on immigration. p. 77. Shepherd 1994, p. 55...
Oakroyd Cash (1933) as Edmund Gilbert I Was a Spy (1933) as Burgomaster Smithy (1933) as John Smith Channel Crossing (1933) as Trotter Marooned (1933)...
to be divine" and that only later was a volcano considered Hephaestus's smithy. Hephaestus was associated by Greek colonists in southern Italy with the...
Regina. Associated Press. February 20, 1956. Retrieved May 7, 2011. Newcomb, Horace (2004). Encyclopedia of Television. CRC Press. p. 50. ISBN 978-1-57958-411-5...
Lormont Royal Navy Naval cargo ship 1927 1,561 Lt. Cdr. Walter Stuart Smithies, RN (retd) 1 1,084 Louise et Marie (AD2) French Navy Naval trawler 1916...
Smithy would make a better Form captain than Cherry." "How do you make that out, fathead—I mean, old fellow!" "Well, Skinner thinks that if Smithy gets...
Etna and the Aeolian islands. Virgil describes the Cyclopes, in Vulcan's smithy forging iron, making a thunderbolt, a chariot for Mars, and Pallas's Aegis...
legends about the Nac Mac Feegle. One, similar to the legend of Wayland's Smithy, says that if you leave sixpence and an unshod horse at a certain Feegle...
discovery of genetic transposition. Mario Capecchi, Martin Evans, and Oliver Smithies were awarded the prize in 2007 for the discovery of a gene targeting procedure...
Francis S. Collins, John R. Riordan, Lap-Chee Tsui, Victor Ling, Oliver Smithies, Edwin M. Southern, E. Donnall Thomas 1991 Sydney Brenner, John E. Sulston...
clearing. This was the site of the village's stray animal pounds and a smithy. It had two pounds, stocks and a whipping post. Whateley Hall was nearby...
Pleasence (Arthur Gladwell), Katharine Blake (Doris Binstead), Harold Scott (Smithy), Murray Melvin (Frank), John Ruddock (Mr Rogers), Felicity Ross (Marlene)...
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