positive regulation of branching involved in ureteric bud morphogenesis
renal system development
regulation of transcription, DNA-templated
epithelial cell differentiation
olfactory placode formation
regulation of skeletal muscle cell differentiation
tongue development
organ induction
kidney development
anatomical structure development
thymus development
ureter smooth muscle cell differentiation
neuron fate specification
myotome development
skeletal system morphogenesis
outflow tract morphogenesis
trigeminal ganglion development
negative regulation of apoptotic process
negative regulation of transcription by RNA polymerase II
hearing
aorta morphogenesis
regulation of branch elongation involved in ureteric bud branching
fungiform papilla morphogenesis
transcription, DNA-templated
generation of neurons
otic vesicle development
regulation of protein localization
positive regulation of transcription, DNA-templated
multicellular organism development
branching involved in ureteric bud morphogenesis
thyroid gland development
inner ear morphogenesis
cochlea morphogenesis
positive regulation of ureteric bud formation
positive regulation of mesenchymal cell proliferation involved in ureter development
middle ear morphogenesis
regulation of synaptic assembly at neuromuscular junction
protein localization to nucleus
regulation of gene expression
embryonic cranial skeleton morphogenesis
inner ear development
positive regulation of secondary heart field cardioblast proliferation
negative regulation of branching involved in ureteric bud morphogenesis
cell population proliferation
regulation of epithelial cell proliferation
regulation of skeletal muscle satellite cell proliferation
skeletal muscle tissue development
metanephric mesenchyme development
facial nerve morphogenesis
positive regulation of transcription by RNA polymerase II
pharyngeal system development
apoptotic process
transcription by RNA polymerase II
cellular response to 3,3',5-triiodo-L-thyronine
negative regulation of transcription, DNA-templated
regulation of skeletal muscle cell proliferation
skeletal muscle fiber development
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6495
20471
Ensembl
ENSG00000126778
ENSMUSG00000051367
UniProt
Q15475
Q62231
RefSeq (mRNA)
NM_005982
NM_009189
RefSeq (protein)
NP_005973
NP_033215
Location (UCSC)
Chr 14: 60.64 – 60.66 Mb
Chr 12: 73.09 – 73.1 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Homeobox protein SIX1 (Sine oculis homeobox homolog 1) is a protein that in humans is encoded by the SIX1 gene.[5][6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000126778 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000051367 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Boucher CA, Carey N, Edwards YH, Siciliano MJ, Johnson KJ (April 1996). "Cloning of the human SIX1 gene and its assignment to chromosome 14". Genomics. 33 (1): 140–2. doi:10.1006/geno.1996.0172. PMID 8617500.
^Ruf RG, Xu PX, Silvius D, Otto EA, Beekmann F, Muerb UT, Kumar S, Neuhaus TJ, Kemper MJ, Raymond RM, Brophy PD, Berkman J, Gattas M, Hyland V, Ruf EM, Schwartz C, Chang EH, Smith RJ, Stratakis CA, Weil D, Petit C, Hildebrandt F (May 2004). "SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes". Proceedings of the National Academy of Sciences of the United States of America. 101 (21): 8090–5. Bibcode:2004PNAS..101.8090R. doi:10.1073/pnas.0308475101. PMC 419562. PMID 15141091.
^"Entrez Gene: SIX1 sine oculis homeobox homolog 1 (Drosophila)".
and 4 Related for: Homeobox protein SIX1 information
cell eukaryotes. Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that...
particularly in fusion. The twist gene plays a role in muscle differentiation. The SIX1 gene plays a critical role in hypaxial muscle differentiation in myogenesis...
Branchial pouches. Thyroid Namely the co-activator EYA1, the homeobox transcription factor SIX1, and the transcription factor GCM2 Gray, Henry (1980). Williams...