Holmes tremor, first identified by Gordon Holmes in 1904, can be described as a wing-beating movement localized in the upper body that is caused by cerebellar damage.[1] Holmes tremor is a combination of rest, action, and postural tremors. Tremor frequency ranges from 2 to 5 Hertz and is aggravated with posture and movement.[1] It may arise from various underlying structural disorders including stroke, tumors, trauma, and other cerebellar lesions.[2] Because Holmes tremor is rare, much of the research is based on individual cases.
The formation of tremors is due to two main factors: the over-excited rhythmic movement of neuronal loops and permanent structural changes from neurodegeneration. Two major neuronal networks, the corticostriatothalamocortical hap and the inferior olivary nucleus (ION) specifically target the development of the tremors.[1] When diagnosing a patient with Holmes tremor, one must look at the neurological signs and symptoms, as well as the possibility that the tremor is caused by medications or other stimulants. In most cases, the patient's history and a targeted neurological examination is enough to give a diagnosis.
Treatment for Holmes tremor is dependent on the characteristics of the tremor. Because the disease is involved with the dopaminergic system, most treatments involve levodopa.[1] Drugs used to treat other types of tremors are applicable to the treatment of Holmes tremor; however, these drugs have a low success rate.[3]
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^Menon, B; Sasikala, P; Agrawal, A (2014). "Giant Middle Fossa Epidermoid Presenting as Holmes' tremor Syndrome". Journal of Movement Disorders. 7 (1): 22–24. doi:10.14802/jmd.14005. PMC 4051724. PMID 24926407.
^Cite error: The named reference Buijink was invoked but never defined (see the help page).
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