Hemoglobin subunit zeta information

HBZ
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JEB, 3W4U
Identifiers
Aliases	HBZ, HBZ-T1, HBZ1, hemoglobin subunit zeta, HBAZ
External IDs	OMIM: 142310 MGI: 96019 HomoloGene: 110705 GeneCards: HBZ
Gene location (Human)
Chr.	Chromosome 16 (human)
End	154,503 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	32,228,116 bp
RNA expression pattern
	Top expressed in
	blood; ; ganglionic eminence; ; bone marrow; ; subcutaneous adipose tissue; ; amygdala; ; placenta; ; monocyte; ; nucleus accumbens; ; hippocampus proper; ; dorsolateral prefrontal cortex;
	Top expressed in
	yolk sac; ; abdominal wall; ; maxillary prominence; ; internal carotid artery; ; external carotid artery; ; hand; ; somite; ; endocardial cushion; ; medial ganglionic eminence; ; atrium;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	iron ion binding; oxygen binding; protein binding; heme binding; metal ion binding; oxygen carrier activity; peroxidase activity; haptoglobin binding; organic acid binding;
Cellular component	hemoglobin complex; extracellular exosome; haptoglobin-hemoglobin complex;
Biological process	oxygen transport; negative regulation of transcription by RNA polymerase II; erythrocyte maturation; transport; hydrogen peroxide catabolic process; protein heterooligomerization; cellular oxidant detoxification;
	Sources:Amigo / QuickGO
Orthologs
	3050
	15126
	ENSG00000130656
	ENSMUSG00000055609
	P02008
	P06467
	NM_005332
	NM_010405
	NP_005323
	NP_034535
	Wikidata
View/Edit Human	View/Edit Mouse

Hemoglobin subunit zeta is a protein that in humans is encoded by the HBZ gene.^[5]^[6]

Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta1 - 3'.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130656 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055609 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (April 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.
^ ^a ^b "Entrez Gene: HBZ hemoglobin, zeta".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130656 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055609 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2649166-5] Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (April 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.

[entrez-6] "Entrez Gene: HBZ hemoglobin, zeta".

Hemoglobin subunit zeta information

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List of human clusters of differentiation

Acute lymphoblastic leukemia