Global InformationHadrucalcin information
Hadrucalcin is a peptide toxin from the venom of the scorpion Hadrurus gertschi.[1] Hadrucalcin modifies the Ryanodine receptor channels RyR1 and RyR2, found in the sarcoplasmic reticulum, to a long-lasting subconductance state, thus inducing the release of calcium from the sarcoplasmic reticulum.[2]
- ^ "Hadrucalcin precursor - Hoffmannihadrurus gertschi (Scorpion)".
- ^ Schwartz EF, Capes EM, Diego-García E, et al. Characterization of hadrucalcin, a peptide from Hadrurus gertschi scorpion venom with pharmacological activity on ryanodine receptors. Br J Pharmacol. 2009;157(3):392-403. doi:10.1111/j.1476-5381.2009.00147.x.