Global InformationVejocalcin information
 3-dimensional modelling of Vejocalcin toxin.[1] | |
| Names and Taxonomy | |
|---|---|
| Recommended name | Vejocalcin |
| Short name | VjCa |
| Organism | Vaejovis mexicanus |
| Taxonomic Identifier | 993612 [NCBI] |
| Taxonomic Lineage | Vaejovis |
| Family and Domains | |
| Domain | Knottin |
| Sequence Similarities | Scorpion Calcin Family |
| InterPro | IPR012632 |
| Pfam | PF08099 |
| PROSITE | PS60028 |
| Identifiers | |
| UniProt | P0DPT1 |
Vejocalcin (VjCa, also called Vejocalcine) is a toxin from the venom of the Mexican scorpion Vaejovis mexicanus. Vejocalcin is a member of the calcin family of toxins. It acts as a cell-penetrating peptide (CPP); it binds with high affinity and specificity to skeletal ryanodine receptor 1 (RYR1) of the sarcoplasmic reticulum, thereby triggering calcium release from intracellular Ca2+ stores.
- ^ Xiao, Liang; Gurrola, Georgina B.; Zhang, Jing; Martin, Mario San; Zamudio, Fernando Z.; Possani, Lourival D.; Valdivia, Héctor H. (2014-01-28). "Structure-Function Relationship of Calcins, a Family of High-Affinity Peptide Ligands of Ryanodine Receptors". Biophysical Journal. 106 (2). Cell: 106–13. Bibcode:2014BpJ...106..106X. doi:10.1016/j.bpj.2013.11.656. PMC 3907369. PMID 24411242.