Global InformationHSD2 neuron information
HSD2 neurons are a small group of neurons in the brainstem which are uniquely sensitive to the mineralocorticosteroid hormone aldosterone, through expression of HSD11B2. They are located within the caudal medulla oblongata, in the nucleus of the solitary tract (NTS). HSD2 neurons are activated during a prolonged deficit in body sodium or fluid volume, as occurs after dietary sodium deprivation or during frank hypovolemia.[1] They are also activated by supraphysiologic stimulation of the mineralocorticoid receptor.[2] They are inactivated when salt is ingested.[1] To date, HSD2 neurons have been identified and studied only in rats and mice.
- ^ a b Geerling, JC; Engeland, WC; Kawata, M; Loewy, AD (Jan 11, 2006). "Aldosterone target neurons in the nucleus tractus solitarius drive sodium appetite". The Journal of Neuroscience. 26 (2): 411–7. doi:10.1523/JNEUROSCI.3115-05.2006. PMC 6674421. PMID 16407537.
- ^ Geerling, JC; Loewy, AD (Oct 18, 2006). "Aldosterone-sensitive NTS neurons are inhibited by saline ingestion during chronic mineralocorticoid treatment". Brain Research. 1115 (1): 54–64. doi:10.1016/j.brainres.2006.07.091. PMID 16935272.