HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072, HOX transcript antisense RNA, HOTAIR long untranslated RNA, human
External IDs
OMIM: 611400 GeneCards: HOTAIR
Gene location (Human)
Chr.
Chromosome 12 (human)[1]
Band
12q13.13
Start
53,962,308 bp[1]
End
53,974,956 bp[1]
RNA expression pattern
Bgee
Human
Mouse (ortholog)
Top expressed in
Achilles tendon
popliteal artery
saphenous vein
skin of abdomen
sural nerve
subcutaneous adipose tissue
gastrocnemius muscle
smooth muscle tissue
urethra
urinary bladder
n/a
More reference expression data
BioGPS
n/a
Orthologs
Species
Human
Mouse
Entrez
100124700
n/a
Ensembl
ENSG00000228630
n/a
UniProt
n a
n/a
RefSeq (mRNA)
n/a
n/a
RefSeq (protein)
n/a
n/a
Location (UCSC)
Chr 12: 53.96 – 53.97 Mb
n/a
PubMed search
[2]
n/a
Wikidata
View/Edit Human
HOTAIR (for HOX transcript antisense RNA)[3] is a human gene located between HOXC11 and HOXC12 on chromosome 12. It is the first example of an RNA expressed on one chromosome that has been found to influence the transcription of the HOXD cluster posterior genes located on chromosome 2. The sequence and function of HOTAIR are different in humans and mice.[4] Sequence analysis of HOTAIR revealed that it exists in mammals, has poorly conserved sequences and considerably conserved structures, and has evolved faster than nearby HoxC genes.[5] A subsequent study identified HOTAIR has 32 nucleotides long conserved noncoding element (CNE) that has a paralogous copy in HOXD cluster region (located between HOXD11 and HOXD12),[6] suggesting that the HOTAIR conserved sequences predate whole genome duplication events at the root of vertebrate. While the conserved sequence paralogous with HOXD cluster is 32 nucleotide long, the HOTAIR sequence conserved from human to fish is about 200 nucleotide long and is marked by active enhancer features (bidirectional transcription, H3K4me1 and H3K27ac peaks).[6]
^ abcGRCh38: Ensembl release 89: ENSG00000228630 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Genecards entry on HOTAIR". Retrieved 20 July 2010.
^Schorderet P, Duboule D (May 2011). "Structural and functional differences in the long non-coding RNA hotair in mouse and human". PLOS Genetics. 7 (5): e1002071. doi:10.1371/journal.pgen.1002071. PMC 3102750. PMID 21637793.
^He S, Liu S, Zhu H (April 2011). "The sequence, structure and evolutionary features of HOTAIR in mammals". BMC Evolutionary Biology. 11 (1): 102. Bibcode:2011BMCEE..11..102H. doi:10.1186/1471-2148-11-102. PMC 3103462. PMID 21496275.
^ abNepal C, Taranta A, Hadzhiev Y, Pundhir S, Mydel P, Lenhard B, et al. (April 2020). "Ancestrally Duplicated Conserved Noncoding Element Suggests Dual Regulatory Roles of HOTAIR in cis and trans". iScience. 23 (4): 101008. Bibcode:2020iSci...23j1008N. doi:10.1016/j.isci.2020.101008. PMC 7139118. PMID 32268280.
HOTAIR (for HOX transcript antisense RNA) is a human gene located between HOXC11 and HOXC12 on chromosome 12. It is the first example of an RNA expressed...
Michelle Malkin, a conservative author and blogger, in 2006, taking over hotair.com from a defunct personal website. Although Malkin served as the publisher...
July 2013. Retrieved 6 July 2013. "Reports: Morsi under house arrest". HotAir. 3 July 2013. Archived from the original on 6 July 2013. Retrieved 3 July...
Ed (March 17, 2013). "Video: Katie Pavlich, CPAC Blogger of the Year". HotAir. Retrieved January 29, 2020. Williams, Rachel (July 11, 2014). "And the...
December 2013. Retrieved 2016-05-12. "Twitchy Sold To Owners Of Townhall And Hotair". BuzzFeed. 10 December 2013. Retrieved 2016-05-12. "Salem Communications...
Benson 2015 Rothstein, Betsy (July 11, 2012). "Ham Now Officially Full of HotAir". FishbowlDC, The Revolving Door. Mediabistro, Inc. Archived from the original...
2019). "Ben Shapiro bashes the alt-right – gets protested by the far-left". HotAir. Archived from the original on January 1, 2020. Retrieved March 7, 2020...
Air (film), a 2019 American comedy-drama film directed by Frank Coraci HOTAIR, a human gene (short for "HOX transcript antisense RNA") Hot air airship...
Johnson, Benny (December 10, 2013). "Twitchy Sold To Owners Of Townhall And Hotair". BuzzFeed News. Archived from the original on March 10, 2021. Retrieved...
290 lncRNAs from around 60 species. Example lncRNAs in the database are HOTAIR and Xist. Amaral, Paulo P; Clark Michael B; Gascoigne Dennis K; Dinger Marcel...
The New York Times. "Rand Paul vs. Washington DC on the USA Freedom Act". HotAir. Archived from the original on 2015-06-02. Retrieved 2015-06-02. Top Level...
coverage from a variety of independent blogs such as digitaltrends.com, hotair.com and intomobile.com, as well as from online news media agencies such...
the asRNA HOTAIR is transcribed from homeobox C (HOXC) locus but it recruits PRC2 to HOXD which deposits H3K27 and silences HOXD. HOTAIR is highly expressed...
abundant in Hox clusters. In humans, 231 ncRNA may be present. One of these, HOTAIR, silences in trans (it is transcribed from the HOXC cluster and inhibits...
discrimination at Evergreen College...against a white male professor". HotAir. Retrieved June 15, 2023. "Day of Absence & Day of Presence Archived 2017-12-26...
a hypocrite about trucker protests, says ... the NYT editorial board?". Hotair. "Canadian news host slammed for suggesting Russia behind massive 'freedom'...
the only candidate at a brokered convention who's satisfied Rule 40?". HotAir. Retrieved March 22, 2016. "Call of the 2016 Republican National Convention"...
Retrieved April 20, 2011. "Madison protests cost WI taxpayers millions", hotair.com, April 20, 2011. "Health Care Bs - State Of Wisconsin Investigating...
Laden, London/New York 2005 "Video: Al Qaeda tells U.S. to convert or die". HotAir. 2 September 2006. Archived from the original on 26 March 2009. Retrieved...
(October 10, 2013). "Rand Paul vs. Washington DC on the USA Freedom Act". HotAir. Archived from the original on 2015-06-02. Retrieved 2015-06-02. "USA Freedom...
Wynn also has been finance chair of the campaigns of Senator Jim DeMint. "Perry backer bails over Bain attacks". Hotair.com. Retrieved 2012-03-14. v t e...
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