Protein-coding gene in the species Homo sapiens
HOXA2 Identifiers Aliases HOXA2 , HOX1K, MCOHI, homeobox A2External IDs OMIM: 604685; MGI: 96174; HomoloGene: 4901; GeneCards: HOXA2; OMA:HOXA2 - orthologs Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p15.2 Start 27,100,354 bp[1] End 27,102,686 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 B3|6 25.4 cM Start 52,139,397 bp[2] End 52,141,811 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon Descending thoracic aorta C1 segment gastric mucosa left uterine tube ascending aorta muscle layer of sigmoid colon body of uterus tibial arteries rectum
Top expressed in neuromere rhombomere tail of embryo thoracic diaphragm main bronchus tongue genital tubercle female urethra hair ureter
More reference expression data
BioGPS
Gene ontology Molecular function
DNA binding
sequence-specific DNA binding
DNA-binding transcription factor activity
RNA polymerase II cis-regulatory region sequence-specific DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
DNA-binding transcription repressor activity, RNA polymerase II-specific
Cellular component
nucleus
intracellular membrane-bounded organelle
Biological process
regulation of transcription, DNA-templated
transcription, DNA-templated
multicellular organism development
negative regulation of transcription by RNA polymerase II
cell fate determination
osteoblast development
segment specification
pattern specification process
motor neuron axon guidance
anterior/posterior pattern specification
dorsal/ventral pattern formation
rhombomere 2 development
rhombomere 3 development
rhombomere 3 morphogenesis
brain segmentation
middle ear morphogenesis
cell fate commitment
negative regulation of neuron differentiation
negative regulation of osteoblast differentiation
positive regulation of transcription by RNA polymerase II
embryonic viscerocranium morphogenesis
embryonic skeletal system morphogenesis
cellular response to retinoic acid
regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 7: 27.1 – 27.1 Mb Chr 6: 52.14 – 52.14 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
Homeobox protein Hox-A2 is a protein that in humans is encoded by the HOXA2 gene.[5]
^ a b c GRCh38: Ensembl release 89: ENSG00000105996 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014704 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Scott MP (November 1992). "Vertebrate homeobox gene nomenclature". Cell . 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
Last Update: 2022-03-30T16:27:58Z
Homeobox protein Hox-A2 is a protein that in humans is encoded by the HOXA2 gene. In vertebrates, the genes encoding the class of transcription factors...
Word Count : 555
Last Update: 2024-04-01T17:54:09Z
Cluster Human Chromosome Genes HOXA@ chromosome 7 HOXA1, HOXA2 , HOXA3, HOXA4, HOXA5, HOXA6, HOXA7, HOXA9, HOXA10, HOXA11, HOXA13 HOXB@ chromosome 17 HOXB1...
Word Count : 6046
Last Update: 2024-04-01T17:00:44Z
name chromosome gene HOXA (or sometimes HOX1) - HOXA@ chromosome 7 HOXA1, HOXA2 , HOXA3, HOXA4, HOXA5, HOXA6, HOXA7, HOXA9, HOXA10, HOXA11, HOXA13 HOXB -...
Word Count : 4469
Last Update: 2023-09-23T02:10:54Z
ENSG00000106031 Homeodomain Known motif – High-throughput in vitro [375] DTTTTATKRS HOXA2 ENSG00000105996 Homeodomain Known motif – High-throughput in vitro [376]...
Word Count : 81
Last Update: 2022-12-06T06:11:52Z
long non-coding RNA gene. In humans, it is located between the HOXA1 and HOXA2 genes. HOTAIRM1 is expressed in cells of a myeloid lineage, and may play...
Word Count : 107
Last Update: 2023-12-03T10:45:24Z
origins of vestibular projection neurons assessed using rhombomere-specific Hoxa2 enhancer elements in the mouse embryo". The Journal of Neuroscience. 27...
Word Count : 2578
Last Update: 2024-06-07T09:02:06Z
Yates JA, Menon T, Thompson BA, Bochar DA (February 2010). "Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8" (PDF)...
Word Count : 1606
Last Update: 2024-02-28T00:52:59Z
defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants". Development. 126 (22): 5011–26. doi:10.1242/dev.126.22.5011. PMID 10529419...
Word Count : 1214
Last Update: 2024-05-09T15:43:25Z
9; 601186; STRA6 Microtia, hearing impairment, and cleft palate; 612290; HOXA2 Microvillus inclusion disease; 251850; MYO5B Migraine, familial basilar;...
Word Count : 18877
Last Update: 2023-12-24T13:41:07Z
Maconochie MK, Neun R, Pattyn A, Chambon P, Krumlauf R, Rijli FM (Apr 1999). "Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral...
Word Count : 940