HHIPL1 information

HHIPL1
Identifiers
Aliases	HHIPL1, KIAA1822, UNQ9245, HHIP like 1
External IDs	MGI: 1919265; HomoloGene: 81985; GeneCards: HHIPL1; OMA:HHIPL1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	99,680,569 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	108,297,128 bp
RNA expression pattern
	Top expressed in
	caudate nucleus; ; cingulate gyrus; ; putamen; ; amygdala; ; nucleus accumbens; ; prefrontal cortex; ; Brodmann area 9; ; stromal cell of endometrium; ; hypothalamus; ; smooth muscle tissue;
	Top expressed in
	uterus; ; visual cortex; ; superior frontal gyrus; ; facial motor nucleus; ; lateral hypothalamus; ; superior colliculus; ; dorsal tegmental nucleus; ; dorsomedial hypothalamic nucleus; ; ventral tegmental area; ; ankle;
	More reference expression data
	n/a
Gene ontology
Molecular function	scavenger receptor activity; catalytic activity; molecular function;
Cellular component	extracellular region; membrane; cellular component;
Biological process	receptor-mediated endocytosis; biological process; vesicle-mediated transport; endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	84439
	214305
	ENSG00000182218
	ENSMUSG00000021260
	Q96JK4
	Q14DK5
	NM_001127258; NM_032425; NM_001329411
	NM_001044380
	NP_001120730; NP_001316340; NP_115801
	NP_001037845
	Wikidata
View/Edit Human	View/Edit Mouse

HHIP-like protein 1 (HHIPL1), also known as HHIP2, is a protein that in humans is encoded by the HHIPL1 gene on chromosome 14.^[5] It is not significantly expressed in many tissues and cell types,^[6] though HHIPL1 mRNA has been detected in trabecular bone cells.^[7] Little is known about the precise biological function of HHIPL1, but the protein has been linked to adenomas.^[8] The HHIPL1 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182218 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021260 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "HHIPL1 HHIP like 1 [Homo sapiens] - Gene". National Center for Biotechnology Information (NCBI). Retrieved 2016-10-06.
^ "BioGPS - your Gene Portal System". biogps.org. Retrieved 2016-10-06.
^ Cite error: The named reference a16391842 was invoked but never defined (see the help page).
^ Duong CV, Emes RD, Wessely F, Yacqub-Usman K, Clayton RN, Farrell WE (December 2012). "Quantitative, genome-wide analysis of the DNA methylome in sporadic pituitary adenomas". Endocrine-Related Cancer. 19 (6): 805–16. doi:10.1530/ERC-12-0251. PMID 23045325.
^ Mega JL, Stitziel NO, Smith JG, Chasman DI, Caulfield MJ, Devlin JJ, et al. (June 2015). "Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials". Lancet. 385 (9984): 2264–71. doi:10.1016/S0140-6736(14)61730-X. PMC 4608367. PMID 25748612.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182218 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021260 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez_gene-5] "HHIPL1 HHIP like 1 [Homo sapiens] - Gene". National Center for Biotechnology Information (NCBI). Retrieved 2016-10-06.

[6] "BioGPS - your Gene Portal System". biogps.org. Retrieved 2016-10-06.

[a16391842-7] Cite error: The named reference a16391842 was invoked but never defined (see the help page).

[a23045325-8] Duong CV, Emes RD, Wessely F, Yacqub-Usman K, Clayton RN, Farrell WE (December 2012). "Quantitative, genome-wide analysis of the DNA methylome in sporadic pituitary adenomas". Endocrine-Related Cancer. 19 (6): 805–16. doi:10.1530/ERC-12-0251. PMID 23045325.

[Mega_2015-9] Mega JL, Stitziel NO, Smith JG, Chasman DI, Caulfield MJ, Devlin JJ, et al. (June 2015). "Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials". Lancet. 385 (9984): 2264–71. doi:10.1016/S0140-6736(14)61730-X. PMC 4608367. PMID 25748612.

HHIPL1 information

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HHIPL1

List of distinct cell types in the adult human body

Chromosome 14