positive regulation of transcription, DNA-templated
cell adhesion
hyaluronan biosynthetic process
extracellular matrix assembly
positive regulation of hyaluranon cable assembly
extracellular polysaccharide biosynthetic process
carbohydrate metabolic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3038
15118
Ensembl
ENSG00000103044
ENSMUSG00000031910
UniProt
O00219
O08650
RefSeq (mRNA)
NM_001199280 NM_005329 NM_138612
NM_008217 NM_001331048
RefSeq (protein)
NP_001186209 NP_005320 NP_619515
NP_001317977 NP_032243
Location (UCSC)
Chr 16: 69.11 – 69.12 Mb
Chr 8: 107.6 – 107.61 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Hyaluronan synthase 3 is an enzyme that in humans is encoded by the HAS3 gene.[5][6][7]
The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Two transcript variants encoding different isoforms have been found for this gene.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000103044 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000031910 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA (Jul 1997). "Chromosomal localization of the human and mouse hyaluronan synthase genes". Genomics. 41 (3): 493–7. doi:10.1006/geno.1997.4696. PMID 9169154.
^Spicer AP, Olson JS, McDonald JA (May 1997). "Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase". J Biol Chem. 272 (14): 8957–61. doi:10.1074/jbc.272.14.8957. PMID 9083017.
Hyaluronan synthase 3 is an enzyme that in humans is encoded by the HAS3 gene. The protein encoded by this gene is involved in the synthesis of the unbranched...
three mammalian hyaluronan synthases described to date - HAS1, HAS2, and HAS3. Each of these isoforms resides at a different chromosome location and has...
is synthesized by three transmembrane synthase proteins HAS1, HAS2, and HAS3. HA, a linear polysaccharide, is composed of repeating disaccharide units...
Operation Paraquet Part of the Falklands War Antrim's Wessex HAS3, nicknamed "Humphrey", preserved at the Fleet Air Arm Museum, played a crucial role in...
hyaluronan synthases, of which vertebrates have three types: HAS1, HAS2, and HAS3. These enzymes lengthen hyaluronan by repeatedly adding D-glucuronic acid...
Jieshou was part of the Yingzhou Prefecture. In the present, Jieshou City has3 sub-districts, 12 towns, and 3 townships. Sub-District Dongcheng (东城街道 :...
Squadron HMS Cardiff 1 Lynx HAS8 of 815 Naval Air Squadron HMS Liverpool 1 Lynx HAS3 of 815 Naval Air Squadron HMS Edinburgh 1 Lynx of 815 Naval Air Squadron...
from County-class destroyers. In 1969, the HAS1 was replaced by the Wessex HAS3. In December 1964, 829 NAS handed over the task of Wasp conversion to 706...
702 was reformed in 1978 and has since operated the Westland Lynx HAS2, HAS3 and HMA8. The squadron is tasked to provide aircrew training and maintenance...
these scales are perforated, forming the true lateral line. The dorsal fin has3 simple and 7-8 branching rays. The tail is forked. The colour of the body...
Global Information
